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NCT ID: NCT05515315 Recruiting - Clinical trials for Immunotherapy Esophagus Cancer

Induction Tislelizumab Combined With Chemotherapy Followed by Definitive Chemoradiotherapy in the Treatment of Locally Unresectable Esophageal Squamous Cell Carcinoma

Start date: May 31, 2022
Phase: Phase 2
Study type: Interventional

To explore the efficacy of Tislelizumab combined with chemotherapy in the treatment of locally unresectable esophageal squamous cell carcinoma (ESCC)

NCT ID: NCT05515289 Recruiting - Breast Cancer Clinical Trials

Study of SHR6390 in Renal Insufficiency and Healthy Subjects

Start date: December 18, 2022
Phase: Phase 1
Study type: Interventional

The study is a single-center, open, single-dose, self-controlled clinical trial. It is planned to enroll 24-30 subjects. Subjects will take the SHR6390 on Day1.

NCT ID: NCT05515185 Not yet recruiting - Clinical trials for Advanced Solid Tumor

B7-H3 Targeting CAR-T Cells Therapy for B7-H3 Positive Solid Tumors

Start date: September 9, 2022
Phase: Early Phase 1
Study type: Interventional

This is a clinical study to evaluate the safety and efficacy of CAR-T cells in the treatment of patients with advanced solid tumors in China.

NCT ID: NCT05515133 Not yet recruiting - Glioblastoma Clinical Trials

Correlation Between Psychological Stress and Disease Progression in Newly Diagnosed Glioblastoma Patients

Start date: December 15, 2022
Phase:
Study type: Observational

It is a single-center, prospective, observational,non-randomized study of newly diagnosed glioblastoma patients conducted in a tertiary hospital. The investigators examine the psychological stress, immune biomarker changes, quality of life, and disease progression of patients with glioblastoma at five-time points. The study had two cohorts, a high-stress cohort and a low-stress cohort, which are grouped after initial recruitment. Both groups undergo total resection of tumors and received 3 months of standardized treatment with radiotherapy and chemotherapy. Neither participants nor doctors but the researcher can choose which group participants are in. No one knows if one study group is better or worse than the other.

NCT ID: NCT05514769 Recruiting - Gastric Cancer Clinical Trials

Proximal Gastrectomy Anterior Anastomosis With Pyloroplasty Versus Esophagogastric Anastomosis for Gastric Cancer

Start date: January 1, 2021
Phase: N/A
Study type: Interventional

This research is designed to compare proximal gastrectomy anterior anastomosis with pyloroplasty with esophagogastric anastomosis for gastric cancer. Gastroesophageal reflux disease, postoperative quality of life, short term outcomes, and long term outcomes will be compared.

NCT ID: NCT05514327 Recruiting - Clinical trials for Diffuse Large B Cell Lymphoma

A Study of Ultra-fraction Radiotherapy Bridging CART in R/R DLBCL

Start date: September 1, 2022
Phase: N/A
Study type: Interventional

This is a single-arm single center study to prospectively evaluate the safety and efficacy of ultra-fraction radiotherapy bridging CAR-T therapy in relapsed/refractory diffuse large b cell lymphoma

NCT ID: NCT05514275 Recruiting - Clinical trials for Nasopharyngeal Carcinoma

Radiotherapy Combined With Endostatin and Capecitabine for NPC

Start date: August 1, 2022
Phase: Phase 2
Study type: Interventional

Radiotherapy combined with recombinant human endostatin and capecitabine for patients with nasopharyngeal carcinoma (NPC) resistant to induction chemotherapy.

NCT ID: NCT05514210 Not yet recruiting - Clinical trials for Coronary Artery Disease

Feasibility and Effectiveness of a Real-time Heart Team Approach in Complex CAD

Start date: June 20, 2023
Phase: N/A
Study type: Interventional

This study is aimed to evaluate the clinical outcomes, efficiency and feasibility of the real-time heart team approach and the conventional heart team approach.

NCT ID: NCT05514158 Recruiting - Gastric Cancer Clinical Trials

To Evaluate the Safety, Tolerability, Pharmacokinetics and Preliminary Efficacy of Disitamab Vedotin Combined With RC98 in the Treatment of Subjects With HER2-expressing Locally Advanced or Metastatic Gastric Cancer (Including AEG)

Start date: September 28, 2022
Phase: Phase 1
Study type: Interventional

This is a single-center, open-label, dose-escalation phase I clinical study.This study aimed to evaluate the safety, tolerability, pharmacokinetics and preliminary clinical efficacy of RC48-ADC combined with RC98 in subjects with advanced gastric cancer.Which will provide a reference basis for dose confirmation in subsequent clinical studies.

NCT ID: NCT05514132 Active, not recruiting - Clinical trials for Advanced Solid Tumours

A Study to Evaluate the Safety and Pharmacokinetics of Ceralasertib in Combination With Durvalumab in Chinese Patients With Advanced Solid Tumours

Start date: September 23, 2022
Phase: Phase 1
Study type: Interventional

This is a Phase 1, open-label study of ceralasertib given in combination with durvalumab in Chinese participants with advanced solid tumours. In each cohort, a monotherapy lead-in period (Cycle 0, duration of 7 or 14 days), prior to dosing with durvalumab, is added to investigate the PK profile and safety/tolerability of ceralasertib in Chinese participants. This study is designed to investigate and characterise preliminary safety, tolerability, and PK of ceralasertib in DLT-evaluable Chinese participants