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NCT ID: NCT05554666 Recruiting - Clinical trials for Advanced Solid Tumors

A Study of ASKG315 in Patients With Advanced Solid Tumors.

Start date: October 15, 2022
Phase: Phase 1
Study type: Interventional

The study is a Phase 1, open-label, multicenter, dose escalation study to evaluate the safety, tolerability, PK and PD of ASKG315 as a single agent in patients with advanced solid tumors.

NCT ID: NCT05554588 Recruiting - Clinical trials for Acute Coronary Syndrome

Intrathrombus Thrombolysis Versus Aspiration Thrombectomy During Primary PCI

ATTRACTIVE
Start date: September 13, 2022
Phase: N/A
Study type: Interventional

This is an multicenter, randomized, controlled, parallel group study. ST-Segment Elevation Myocardial Infarction (STEMI) patients with high thrombus burden(HTB) will be allocated to one of the following: intrathrombus thrombolysis or manual aspiration thrombectomy during primary percutaneous coronary intervention(PPCI).

NCT ID: NCT05554575 Recruiting - Clinical trials for T Cell Lymphoblastic Lymphoma

Chimeric Antigen Receptor T-Cell (CAR-T) Cells in Patients With R/R T-LBL

Start date: October 2022
Phase: Phase 1
Study type: Interventional

This is a single center, single arm, open-lable phase I study to determine the safety and efficacy of T cells expressing CD7 chimeric antigen receptors (referred to as "BT-007 CAR-T cells") in patients with relapsed or refractory acute T cell lymphoblastic lymphoma (R/R T-LBL).

NCT ID: NCT05554276 Recruiting - Cervical Cancer Clinical Trials

Neoadjuvant Chemotherapy Combined With PD-1 + Radical Radiotherapy in Locally Advanced Cervical Cancer

PD-1
Start date: August 1, 2023
Phase: Phase 2
Study type: Interventional

Based on various external factors and differences in the basic characteristics of patients, in my country, it is not clear whether concurrent chemoradiotherapy can achieve optimal therapeutic effect in patients with pathologically diagnosed stage IIB or above locally advanced cervical cancer. Under the limitations of radiotherapy and surgery conditions in the region, some patients will try neoadjuvant chemotherapy combined with PD-1 antibody therapy before standard radiotherapy, hoping to reduce cancer focus and reduce infiltration. Thereby reducing the scope of radiotherapy, better ensure the efficacy of late radiotherapy and chemotherapy and reduce the side effects of radiotherapy. Judging from the review of such patients, neoadjuvant chemotherapy combined with PD-1 antibody therapy + radical radiotherapy seems to have certain efficacy and tolerance in the near future as expected. No statistical analysis has been done on the long-term survival of patients. This topic intends to treat inoperable locally advanced cervical cancer patients with neoadjuvant chemotherapy combined with PD-1 antibody + radical radiotherapy, and explore the treatment-related toxic and side effects and efficacy of neoadjuvant chemotherapy combined with PD-1 antibody + radical radiotherapy. It is hoped that through this study, it will provide a reference for the comprehensive treatment of inoperable locally advanced cervical cancer that has been pathologically diagnosed in the future.

NCT ID: NCT05553990 Recruiting - Clinical trials for Ischemic Stroke, Acute

Predictive Value of Human Microbiome and Serological Markers for Clinical Outcome of AIS With Active Cancer

Start date: June 7, 2020
Phase:
Study type: Observational

Explore with active cancer patients with acute ischemic stroke in the human body characteristic microorganism disorder to clinical prognosis of the predictive value of the secondary objective: to observe with active cancer patients with acute ischemic stroke in the body of microorganisms and their serological indexes change law of exploration condition change related biomarkers of microscopic objects group based on the human body.

NCT ID: NCT05553886 Recruiting - Clinical trials for Chronic Heart Failure With Reduced Ejection Fraction

S086 Tablets for Chronic Heart Failure With Reduced Ejection Fraction

Start date: December 21, 2021
Phase: Phase 3
Study type: Interventional

A randomized, double-blind, positive-drug parallel controlled, multicenter phase III trial of the efficacy and safety of S086 tablets in patients with chronic heart failure with reduced ejection fraction (HFrEF)

NCT ID: NCT05553626 Not yet recruiting - Heart Failure Clinical Trials

Safety and Effectiveness of Left Bundle Branch Pacing in Patients With Cardiac Dysfunction and AV Block

Start date: September 2022
Phase: N/A
Study type: Interventional

This study is a multicenter, prospective, randomized study to assess if cardiac dysfunction patients with LVEF <50% and the estimated ventricular pacing percentage >40% with LBBP have the non-inferior safety and efficacy than CRT on patients' cardiac function and prognosis

NCT ID: NCT05553431 Recruiting - Clinical trials for Left Bundle Branch Pacing

Feasibility of Simplified Permanent Left Bundle Branch Pacing Without Electrophysiological Recording System

Start date: September 2022
Phase: N/A
Study type: Interventional

This is a prospective, single-center study of patients with an indication for ventricular pacing who attempted LBBP without electrophysiology recording system (EP system).

NCT ID: NCT05553093 Recruiting - Clinical trials for Type 2 Diabetes Mellitus

Effects of Tirzepatide and Insulin Glargine on Glucolipid Metabolism and Brain Function in Patients With Type 2 Diabetes

Start date: March 15, 2022
Phase: Phase 4
Study type: Interventional

The effects of Tirzepatide and Insulin Glargine on glucose and lipid metabolism and inflammation in patients with type 2 diabetes mellitus. Effects of Tirzepatide on the occurrence and development of cognitive impairment in diabetic patients and its associated pattern of changes in brain neural network characteristics.

NCT ID: NCT05553015 Recruiting - Clinical trials for Pulmonary Hypertension

A Real-World Registry Investigating TReprostInil sodiUM in Pulmonary Hypertension (Re-TRIUMPH)

Start date: December 24, 2020
Phase:
Study type: Observational [Patient Registry]

A Real-World Registry investigate Treprostinil sodium used in patients with Pulmonary Hypertension (Re-TRIUMPH).