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NCT ID: NCT05275764 Recruiting - Congenital Cataract Clinical Trials

Comparison of the Efficacy of Intraocular Lens Optic Capture and In-the-bag Implantation Over 1 Year in Children With Congenital Cataract

Start date: November 1, 2021
Phase:
Study type: Observational

Approximately 30 eyes with congenital cataract who underwent primary or secondary intraocular lens implantation surgery at Zhejiang Eye Hospital from March 2018 to December 2020 were enrolled. According to the implantation method of IOL, patients were devided into the optic capture group and the endocapsular group. And through the clinical parameters of postoperative best corrected visual acuity (BCVA), intraocular pressure (IOP), IOL position and whether appear visual axis opacity to compare the outcome of the 2 IOL implantation methods.

NCT ID: NCT05275569 Recruiting - Cancer Clinical Trials

Personalized Electroacupuncture Treatment for Chemotherapy-induced Nausea and Vomiting in Breast Cancer (PET)

Start date: March 15, 2022
Phase: N/A
Study type: Interventional

This study aims to evaluate electroacupuncture as an antiemetic treatment compared with sham acupuncture in patients with breast cancer, receiving highly emetogenic chemotherapy (HEC). Moreover, it will analyze the association between single nucleotide polymorphism and the antiemetic outcomes of electroacupuncture.

NCT ID: NCT05275296 Recruiting - Clinical trials for Cardiovascular Diseases

Registration Trial of the Intracranial Visualized Stent for the Wide-necked Intracranial Aneurysms

PROMISE
Start date: January 24, 2022
Phase: N/A
Study type: Interventional

A registration trial of the Intracranial Visualized stent in the treatment of wide-necked intracranial aneurysms

NCT ID: NCT05275088 Recruiting - Clinical trials for Failed Prosthetic Atrioventricular Valve/ Annulus Repair

Prizvalve® Transcatheter Atrioventricular Valve Replacement Study

Start date: March 9, 2022
Phase: N/A
Study type: Interventional

To evaluate the safety and performance of the Prizvalve® system in patients with severe atrioventricular annular calcification or failed prosthetic atrioventricular valve/ annulus repair.

NCT ID: NCT05275062 Recruiting - Pancreatic Cancer Clinical Trials

Clinical Trial to Evaluate the Safety and Efficacy of IM92 CAR-T Cells Therapy in Patients With Advanced Gastric or Pancreatic Adenocarcinoma

Start date: February 15, 2022
Phase: Early Phase 1
Study type: Interventional

This is a open-label, single center to determine the efficacy and safety of IM92 CAR-T cells in Patients With advanced gastric/esophagogastric combination adenocarcinoma that has failed at least second-line therapy and advanced pancreatic cancer that has failed at least first-line therapy.

NCT ID: NCT05275036 Recruiting - Lymphoma Clinical Trials

Assessment of Early-detection Based on Liquid Biopsy in Lymphoid Malignancies

ASCEND-LYM
Start date: May 31, 2022
Phase:
Study type: Observational

ASCEND-LYM is a prospective, multi-center, observational study aimed at detecting early stage lymphoma and constrcuting prognostic model by combined assays of cfDNA methylation and other biomarkers. The study will enroll approximately 493 participants including lymphoid malignancies and benign diseases.

NCT ID: NCT05274789 Recruiting - Delirium in Old Age Clinical Trials

Effect of Intraoperative Dexmedetomidine on Postoperative Delirium in Elderly Patients Undergoing Robot-assisted Pancreaticoduodenectomy: a Randomized Controlled Study

Start date: April 15, 2022
Phase: N/A
Study type: Interventional

To observe the effect of intraoperative dexmedetomidine on the incidence of postoperative delirium, postoperative analgesic drug requirements and pain scores in elderly patients undergoing robot-assisted pancreaticoduodenectomy.

NCT ID: NCT05274438 Recruiting - Advanced Melanoma Clinical Trials

Imatinib and Toripalimab in Patients With Locally Advanced/Metastatic Melanoma Harbored With CKIT Mut

Start date: January 26, 2021
Phase: Phase 2
Study type: Interventional

It is a single-center, single-arm Phase II clinical study. This clinical trial aimed to evaluate the PFS of imatinib combined with toripalimab in stage III unresectable and stage IV melanoma with CKIT gene mutation.

NCT ID: NCT05273944 Recruiting - Breast Cancer Clinical Trials

Bioequivalence Study of Doxorubicin Hydrochloride Liposome Injection (Lipodox®) in Chinese Patients

Start date: July 28, 2021
Phase: Phase 1
Study type: Interventional

Bioequivalence study is proposed to be carried out on patients of breast cancer/ ovarian cancer, who are administrated for Doxorubicin Hydrochloride Liposomal Injection Lipodox® or Caelyx® in a dose of 50 mg/m2.

NCT ID: NCT05273840 Recruiting - Obesity Clinical Trials

Effect of Nutritional Supplements on Clinical Outcomes in Patients With Prediabetes and Obesity

Start date: June 11, 2021
Phase: N/A
Study type: Interventional

This study aims to improve blood glucose and weight in patients with prediabetes and obesity through health education, nutritional supplement interventions, clinical evaluation, and close clinical follow-up.100 patients with prediabetes with obesity were randomly divided into 2 groups: life intervention group, nutritional supplement intervention group. All enrolled participants were recommended for routine diabetes lifestyle education according to the "Expert Consensus on Prediabetes Intervention in Adults in China". The duration of the intervention was 3 months. The investigators aimed to compare the differences in weight, glycosylated hemoglobin, lipids and other indicators of the two groups of included populations before and after the intervention. In addition, the investigators are to explore the effects of nutritional supplement interventions on glycolipid metabolism and body weight in prediabetes with obesity.