There are about 28871 clinical studies being (or have been) conducted in Canada. The country of the clinical trial is determined by the location of where the clinical research is being studied. Most studies are often held in multiple locations & countries.
To confirm the long-term efficacy and safety of Bronchial Thermoplasty (BT) at 10 years follow-up or beyond in subjects previously enrolled in any of the following Boston Scientific-sponsored, controlled pre-approval studies: AIR, RISA and AIR2.
Results from this study will be used to verify that the published pediatric reference intervals are met on the DxH 520 Hematology Analyzer for the pediatric age ranges.
Parkinson's disease (PD) affects more than 100,000 Canadians and results in symptoms affecting both motor and cognitive (thinking and memory) functions. Parkinson's disease with Mild Cognitive Impairment (MCI) frequently results in development of dementia for which few treatment options exist. Transcranial Magnetic Stimulation (TMS) is used to alter activity in the outer regions of the brain and has been shown in previous studies to increase cognitive performance in patients with different disorders. This study will investigate the effectiveness of TMS as a clinical treatment for the cognitive deficits associated with Parkinson's disease. 64 male and female participants between the ages of 50 and 90 will attend eight study visits over a period of 63 to 66 days. This study is a double-blind randomized clinical trial meaning the participant will be assigned by chance to either the TMS-treatment group or the Sham-treatment group. Additionally, a combination of memory and thinking tests and Magnetic Resonance Imaging (MRI) will be used to see if there are structural and functional changes within the brain. Genotyping and blood analysis before and after treatment for different biomarkers will also be performed and these data will be compared to the TMS data. Initially, this research will increase knowledge about the effects of TMS on various brain regions. Ultimately, we will be able to determine if TMS can be used as a complementary therapy for PD to improve cognitive performance and to reduce progression into dementia.
Binocular vision tests are guided by the principle that uniform motion and focus of the eyes may be trained, but exercising the simultaneous movement of the pupils is necessary and important in achieving optimal and lasting results (Horwood & Toor, 2014). These tests have been in use for over 70 years and represent the foundation of therapy for visual deficiencies such as the inability of the eyes to move together. Despite their frequent use, no one has ever formally evaluated how good these tests are. One such evaluation method is reliability. A reliable test is one that will give the same result when repeated on multiple occasions (i.e. test-retest reliability) or by different people (inter-rater reliability). An unreliable test gives widely varying results when repeated, which would make changes in a patient's test results difficult to interpret. Therefore, this study aims to determine the test-retest reliability of seven binocular vision tests across two independent measurements. The investigators will measure 20 healthy people ages 18 to 35 years for each of these tests on two separate occasions, one week apart. Since these tests have been in use for many years, we are expecting the two measurements to be within acceptable range of each other. The tests being investigated measure: 3D vision (i.e. gross stereoscopic acuity), uniform movement of the eyes (i.e. "motor punctum proximum"), ability of the eyes to adapt to a target moving towards and/or away from the eyes (i.e. binocular fusion with convergence and divergence), quick movements of the eyes (i.e. saccadic movements), natural alignment of the eyes (i.e. anatomic oculomotor deviation), and double vision as a target is moved towards the eyes (i.e. convergence fusional proximum). The results of each test will be analyzed individually. If the tests are perfectly reliable, we would expect the results of the first test to equal the results of the second test for each participant. To examine the test-retest reliability the difference between the first and second test for each individual and across all individuals' scores summed together will be assessed.
Primary Objective: To demonstrate the superiority of Sotagliflozin 200 milligrams (mg) and Sotagliflozin 400 mg versus placebo on HbA1c reduction at 26 Weeks in participants with Type 2 diabetes who have inadequate glycemic control and moderate renal impairment. Secondary Objectives: - To assess the effects of Sotagliflozin 200 mg and 400 mg versus placebo with respect to additional measures of glycemic control, blood pressure, and body weight. - To evaluate the safety of Sotagliflozin 200 mg and 400 mg versus placebo.
The study is open-label with a randomized, cross-over design using standard Gl methodology.
The primary objectives of this study are to: 1) develop an educational tool known as the Patient Reported Outcome Measure informed Decision Aid (PROM-DA) that will describe the options for patients considering total knee arthroplasty (TKA) surgery, and help them imagine what to expect if they choose either option; 2) assess the extent that the PROM-DA improves patients decision quality; 3) determine the feasibility of a larger trial to test the PROM-DA in multiple sites and more patients.
Clerkship causes significant stress to medical students. Some interventions to increase well-being have been described but none have been studied prospectively in this context. The primary objective of this study is to examine the effects of gratitude journaling on medical clerks' perceived well-being. Students will be randomised to one of two groups: gratitude journaling or no intervention. The participants of the experimental group will be asked to complete an online gratitude journal 3 times per week and will be compared to the participants in the control group. The students in both groups will answer a standardised questionnaire evaluating well-being before and after their surgical rotation. Those randomised to the intervention group will perform gratitude journaling three times a week during their surgical rotation. This activity consists of writing something that made them feel happy during their day. Those randomised in the control group (no intervention) will proceed with their normal rotation, without additional gratitude journaling. The main outcome will be evaluated by comparing the well-being at the end of the surgical rotation as evaluated by a composite well-being assessment scale between both groups.
This is a randomized study intended to produce a reduction in ordering of inappropriate tests by general practitioners as determined by recommendations from the CRA's Choosing Wisely guidelines. This reduction of inappropriate testing is expected in referrals to the rheumatologists randomized to the intervention group. This study will further explore which recommendations from the Canadian Rheumatology Association (CRA)/Canada Choosing Wisely campaign have the most impact on regional referring physicians to the Rheumatology clinic at St. Joseph's Hospital, London.
Sometimes people with health conditions become ill suddenly and can no longer speak for themselves and another person (such as a family member) will make health care decisions for them. This means it is important to think about your wishes and tell others about them. This is called advance care planning. When people have done advance care planning, if they become very sick and cannot speak for themselves they are more likely to get the kind of health care they want and it is easier for the people who make decisions for them. There are tools such as brochures, questionnaires, and videos that can help people learn about these things. This research is being to done to study whether using tools for advance care planning and goals of care discussions will improve how patients and their substitute decision makers do advance care planning. This study is a randomized trial. This means half of the people in this study will meet with someone at their family practice to talk about advance care planning and review some tools and half will get usual care (a Speak Up workbook). The study will 1) evaluate if reviewing the tools, and having help to complete them, helps patients and their substitute decision maker do advance care planning 2) if this intervention will encourage patients to talk to their family doctor about these issues.