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NCT ID: NCT00075218 Completed - Clinical trials for Gastrointestinal Stromal Tumor

A Study To Assess The Safety And Efficacy Of SU11248 In Patients With Gastrointestinal Stromal Tumor(GIST)

Start date: December 2003
Phase: Phase 3
Study type: Interventional

A study to assess the safety and efficacy of SU11248 in patients with gastrointestinal stromal tumor (GIST) whose disease has failed imatinib therapy or who were intolerant to imatinib treatment.

NCT ID: NCT00074906 Completed - Pneumonia Clinical Trials

Venticute in Patients With Pneumonia or Aspiration of Gastric Contents and Intubation/Ventilation/Oxygenation Impairment (BY2001/M1-007)

Start date: November 2003
Phase: Phase 3
Study type: Interventional

Study to demonstrate that administration of Venticute increases survival of patients with pneumonia or aspiration of gastric contents leading to intubation, mechanical ventilation, and severe oxygenation impairment.

NCT ID: NCT00074828 Completed - Clinical trials for Total Knee Replacement

New Oral Anticoagulant Therapy for the Prevention of Blood Clots Following Hip or Knee Replacement Surgery

Start date: December 2003
Phase: Phase 2
Study type: Interventional

LY517717 (a capsule given by mouth) is a blood thinner that may prevent blood clots from forming in the legs and may prevent those blood clots from traveling to the lungs. Leg and lung blood clots occur commonly after patients have surgery to replace a hip or knee joint. These clots often occur while patients are in bed in the hospital after hip or knee joint surgery. The purpose of this study is to test if different dose strengths (amount of drug in the capsules) of LY517717 can prevent blood clots from forming and to determine if LY517717 is safe. This study will compare LY517717 to enoxaparin, another blood thinner. Enoxaparin is one of the standard medications given after hip or knee joint surgery.

NCT ID: NCT00074074 Completed - Clinical trials for Myelodysplastic Syndromes

Infliximab in Treating Patients With Myelodysplastic Syndrome

Start date: October 2003
Phase: Phase 2
Study type: Interventional

RATIONALE: Monoclonal antibodies, such as infliximab, can locate tumor cells and either kill them or deliver tumor-killing substances to them without harming normal cells. PURPOSE: Randomized phase II trial to study the effectiveness of infliximab in treating patients who have myelodysplastic syndrome.

NCT ID: NCT00073749 Completed - Lymphoma, B-Cell Clinical Trials

Study Evaluating CMC-544 In B-Cell Non-Hodgkin's Lymphoma

Start date: August 2003
Phase: Phase 1
Study type: Interventional

To determine the Maximum Tolerated Dose (MTD), the tolerability, and the initial safety profile of CMC-544 in subjects with B-cell Non-Hodgkin's Lymphoma (NHL).

NCT ID: NCT00073502 Completed - Clinical trials for Gastric Adenocarcinoma

Phase II Study of Single Agent OSI-7904L in Patients With Gastric or Gastroesophageal (GEJ) Cancer

Start date: October 2003
Phase: Phase 2
Study type: Interventional

Multi-center, open-label, non-randomized Phase II study to evaluate the efficacy and safety of OSI-7904L in gastric and GEJ cancers. Those patients who do not derive clinical benefit after two cycles may be switched to a commonly used combination regimen.

NCT ID: NCT00073307 Completed - Clinical trials for Carcinoma, Renal Cell

Study of BAY43-9006 in Patients With Unresectable and/or Metastatic Renal Cell Cancer

Start date: November 2003
Phase: Phase 3
Study type: Interventional

The purpose of this study is to evaluate safety, efficacy (including quality of life), and pharmacokinetics of BAY43-9006 when added to Best Supportive Care in patients with unresectable and/or metastatic renal cell cancer, who have received one prior systemic regimen for advanced disease.

NCT ID: NCT00073047 Completed - Ulcerative Colitis Clinical Trials

Humanized Anti-IL-2 Receptor Monoclonal Antibody in Moderate-to-severe Ulcerative Colitis

Start date: April 2003
Phase: Phase 2
Study type: Interventional

The purpose of The PROSPECT Study is to evaluate an investigational medication for the treatment of moderate to severe ulcerative colitis. This study is being conducted at up to 38 clinical research centers in the US, Canada, and Belgium, and is open to male and female patients 12 years and older. Participants in the study will have a number of visits to a research center over a five-month period. All study related care and medication is provided to qualified participants at no cost: this includes all visits, examinations, and laboratory work.

NCT ID: NCT00072930 Completed - Prostate Cancer Clinical Trials

MEDI-522 in the Treatment of Patients With Metastatic Androgen-Independent Prostate Cancer

Start date: December 2003
Phase: Phase 2
Study type: Interventional

The primary objectives of this study are: 1. To explore the antitumor activity of MEDI-522 in combination with docetaxel, prednisone, and zoledronic acid in patients with metastatic Androgen-Independent Prostate Cancer (AIPC); and 2. To summarize the safety of MEDI-522 in combination with docetaxel, prednisone, and zoledronic acid in this patient population.

NCT ID: NCT00072709 Completed - Clinical trials for Amyotrophic Lateral Sclerosis

Study Evaluating TCH346 and Placebo Administered Once Daily in Patients With Amyotrophic Lateral Sclerosis (ALS)

Start date: September 2003
Phase: Phase 2
Study type: Interventional

This is a global multicenter study designed to evaluate the safety and clinical effects of 4 oral doses of TCH346 (1.0, 2.5, 7.5, and 15 mg) compared to placebo in patients with mild or mild to moderate stages of ALS. The study consists of 3 phases: screening (up to 2 weeks), run-in (16 weeks), and a double-blind treatment phase of variable duration (at least 24 weeks).