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NCT ID: NCT00426556 Completed - Clinical trials for Metastatic Breast Cancer

Efficacy and Safety of Everolimus in Combination Therapy, in Patients With HER2-overexpressing Metastatic Breast Cancer

Start date: July 2007
Phase: Phase 1
Study type: Interventional

Phase I: will look at different dose levels and regimens of everolimus combined with weekly trastuzumab and paclitaxel therapy in patients with HER-2 overexpressing metastatic breast cancer. Phase II: will assess the efficacy and safety of the 10mg daily dose of everolimus combined with weekly trastuzumab and paclitaxel therapy in patients with HER-2 overexpressing metastatic breast cancer.

NCT ID: NCT00426530 Completed - Breast Neoplasms Clinical Trials

Safety of Everolimus in Combination Therapy, in Patients With HER2-overexpressing Metastatic Breast Cancer

Start date: February 2007
Phase: Phase 1
Study type: Interventional

This study will look at different dose levels and regimens of everolimus combined with weekly trastuzumab and vinorelbine therapy in patients with HER-2 overexpressing metastatic breast cancer.

NCT ID: NCT00425854 Completed - Breast Neoplasms Clinical Trials

An Open Label Phase II Trial of BIBW 2992 in Patients With HER2-negative Metastatic Breast Cancer

Start date: November 2006
Phase: Phase 2
Study type: Interventional

The purpose of this trial is to evaluate the efficacy, safety and pharmacokinetics of BIBW 2992, a dual, irreversible EGFR- and HER2-inhibitor, in two cohorts of patients with HER2-negative breast cancer after failure of no more than three regimen of prior chemotherapy.

NCT ID: NCT00425555 Completed - Clinical trials for Cutaneous T-Cell Lymphoma

Study of Oral LBH589 in Adult Patients With Refractory Cutaneous T-Cell Lymphoma

Start date: January 2007
Phase: Phase 2
Study type: Interventional

This study will evaluate the safety and efficacy of LBH489B in adult patients with refractory Cutaneous T-Cell Lymphoma.

NCT ID: NCT00425542 Completed - Pulmonary Embolism Clinical Trials

Safety Study of Outpatient Treatment for Pulmonary Embolism

OTPE
Start date: January 2007
Phase: Phase 3
Study type: Interventional

The purpose of this randomized clinical trial is to determine whether outpatient treatment is as effective and safe as inpatient treatment among low-risk patients with pulmonary embolism.

NCT ID: NCT00425100 Completed - Overactive Bladder Clinical Trials

A Clinical Trial To Assess Fesoterodine On Treatment Satisfaction And Symptom Improvement In Overactive Bladder Patients

Start date: January 2007
Phase: Phase 3
Study type: Interventional

To evaluate the effect of fesoterodine on patient satisfaction and overactive bladder (OAB) symptom relief in OAB patients who were dissatisfied with their prior therapy with tolterodine.

NCT ID: NCT00424632 Completed - Solid Tumors Clinical Trials

Phase 1 Study Of Aurora Kinase Inhibitor PF-03814735 In Patients With Advanced Solid Tumors

Start date: November 2006
Phase: Phase 1
Study type: Interventional

The purpose of this study is to determine the maximum tolerated dose and recommended phase 2 dose of PF-03814735 administered orally as single agent in patients with advanced solid tumors.

NCT ID: NCT00424346 Completed - Clinical trials for Rheumatoid Arthritis

Efficacy, Safety and Tolerability of ACZ885 in Patients With Active Rheumatoid Arthritis

Start date: November 2006
Phase: Phase 2
Study type: Interventional

The 12-week core study was designed to evaluate risk-benefit of three subcutaneous dose regimens of ACZ885, added on to stable methotrexate (MTX) therapy (greater than or equal to 7.5 mg/week), compared to placebo in patients with active rheumatoid arthritis (RA). The study investigated the magnitude of effect as well as onset of effect for the different dose regimens. The primary objective of the extension studies was to assess long-term safety and tolerability of canakinumab (ACZ885) in patients with active RA. CACZ885A2201E1 evaluated this objective in patients who had participated in the core study (CACZ885A2201) and CACZ885A2201E2 did the same in patients who completed the first extension study.

NCT ID: NCT00424047 Completed - Multiple Myeloma Clinical Trials

A Study of CC-5013 Plus Dexamethasone Versus Dexamethasone Alone in Previously Treated Subjects With Multiple Myeloma

Start date: January 1, 2003
Phase: Phase 3
Study type: Interventional

To compare the efficacy of oral CC-5013 in combination with oral pulse high-dose dexamethasone to that of placebo and oral high-dose pulse dexamethasone as treatment for subjects with relapsed or refractory multiple myeloma."

NCT ID: NCT00423891 Completed - Clinical trials for Hepatitis B, Chronic

A Study of Entecavir in Pediatric Patients With Chronic Hepatitis B Virus (HBV)-Infection

Start date: June 30, 2007
Phase: Phase 1/Phase 2
Study type: Interventional

The purpose of this clinical study is to determine the appropriate doses of entecavir to use in children and adolescents. Safety, tolerability and efficacy will also be studied