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NCT ID: NCT00423319 Completed - Pulmonary Embolism Clinical Trials

Study of an Investigational Drug for the Prevention of Thrombosis-related Events Following Hip Replacement Surgery (ADVANCE-3)

Start date: March 2007
Phase: Phase 3
Study type: Interventional

The purpose of this study is to learn whether apixaban can prevent the blood clots in the leg (deep vein thrombosis) and lung (pulmonary embolism) that sometimes occur after hip replacement surgery and to learn how apixaban compares with enoxaparin in preventing these clots. The safety of apixaban will also be studied

NCT ID: NCT00422435 Completed - Coronary Disease Clinical Trials

CoStarâ„¢ Paclitaxel-Eluting Coronary Stent Catheter System Evaluation

Start date: January 2007
Phase: Phase 3
Study type: Interventional

This study is designed to evaluate the performance and safety of a new catheter system.

NCT ID: NCT00422422 Completed - Epilepsy Clinical Trials

Open-label, Pharmacokinetic, Safety and Efficacy Study of Adjunctive Brivaracetam in Children With Epilepsy.

Start date: July 2011
Phase: Phase 2
Study type: Interventional

Initial study in children with epilepsy to evaluate the pharmacokinetics, safety, tolerability and preliminary efficacy of adjunctive treatment with brivaracetam, and to develop dosing adaptations for future studies.

NCT ID: NCT00422383 Completed - Clinical trials for Rheumatoid Arthritis

A Study of Retreatment With MabThera (Rituximab) in Combination With Methotrexate in Patients With Rheumatoid Arthritis (RA)

Start date: February 2006
Phase: Phase 3
Study type: Interventional

This study will evaluate the efficacy and safety of various treatment and retreatment regimens of MabThera. All patients will receive concomitant methotrexate, 10-25mg once weekly either orally or parenterally. The anticipated time on study treatment is 2+ years, and the target sample size is 100-500 individuals.

NCT ID: NCT00422149 Completed - Clinical trials for Rhinitis, Allergic, Seasonal

Twin SUBLIVAC® Grasses Clinical Efficacy Study

Start date: September 2006
Phase: Phase 3
Study type: Interventional

To show that treatment with SUBLIVAC® Grasses is clinically effective by means of reduction in allergic symptoms and/or use of allergic symptomatic medication in subjects suffering from IgE mediated allergic complaints triggered by grass pollen.

NCT ID: NCT00422058 Completed - Obesity Clinical Trials

The Effect of Liraglutide on Body Weight in Obese Subjects Without Diabetes

Start date: January 10, 2007
Phase: Phase 2
Study type: Interventional

This trial is conducted in Europe. The purpose of the 20-week trial is to investigate the efficacy of liraglutide to induce body weight loss and the purpose of the extension is to evaluate the long term safety and tolerability of liraglutide. Trial has the following trial periods: A 20-week randomised, double-blind, placebo-controlled, six-armed parallel-group, multi-centre, multinational trial with an open label orlistat comparator arm followed by an 84 week extension period.

NCT ID: NCT00421980 Completed - Clinical trials for Ankylosing Spondylitis

An Open-Label, Multicentre, Long-Term Extension Study of Etanercept in Ankylosing Spondylitis

Start date: June 2002
Phase: Phase 3
Study type: Interventional

The primary objective of this study was to determine the long-term safety of etanercept in adults with AS who had completed study 0881A3-311-EU.

NCT ID: NCT00421200 Completed - Hypotension Clinical Trials

Phase III Study of Hemospan® to Prevent Hypotension in Hip Arthroplasty

Start date: February 2007
Phase: Phase 3
Study type: Interventional

The purpose of this study is to determine whether Hemospan is superior to Voluven for preventing hypotensive episodes during the perioperative period (from induction of spinal anesthesia until 6 hours after skin closure), and for reducing the incidence of operative and postoperative complications including organ dysfunction and failure until follow-up at one month following surgery. An independent Data Safety Monitoring Board (DSMB) will periodically evaluate the safety data collected during this trial.

NCT ID: NCT00421109 Completed - Urticaria Clinical Trials

Efficacy Study for the Symptomatic Treatment of Chronic Idiopathic Urticaria

Start date: July 2006
Phase: Phase 3
Study type: Interventional

The objective of the study is to evaluate the efficacy and tolerability of Bilastine 20 mg Q.D., compared to Levocetirizine 5 mg Q.D. and placebo for the treatment of Chronic Idiopathic Urticaria.

NCT ID: NCT00420927 Completed - Clinical trials for Rheumatoid Arthritis

Study of the Optimal Protocol for Methotrexate and Adalimumab Combination Therapy in Early Rheumatoid Arthritis

OPTIMA
Start date: December 2006
Phase: Phase 4
Study type: Interventional

This study compared the safety and efficacy of combination therapy with adalimumab plus methotrexate (MTX) to that of MTX monotherapy (i.e., placebo plus MTX) in subjects with early rheumatoid arthritis (RA).