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NCT ID: NCT00430534 Completed - Clinical trials for Epstein Barr Virus (EBV) Infection

Evaluation of Safety, Immune-Response and Efficacy of GSK Biologicals’ EBV (Epstein Barr Virus) Vaccine (268664).

Start date: n/a
Phase: Phase 2
Study type: Interventional

To evaluate the safety, immune-response and efficacy of GSK Biologicals’ EBV vaccine in a population at risk of developing infectious mononucleosis. Each subject will receive three doses of vaccine or placebo during the study period.

NCT ID: NCT00430365 Completed - Myeloma Clinical Trials

Maintenance Therapy Using Lenalidomide in Myeloma

IFM2005-02
Start date: June 2006
Phase: Phase 3
Study type: Interventional

Maintenance treatment of myeloma.

NCT ID: NCT00430326 Completed - Varicose Veins Clinical Trials

Juvista (Avotermin) in Scars Following Varicose Vein Removal

Start date: November 2006
Phase: Phase 2
Study type: Interventional

This trial is being undertaken to investigate the efficacy and safety of Juvista in the improvement of scar appearance when administered to approximated wound margins following varicose vein surgery. The results from this trial will be used to select doses for investigation in future clinical trials with the compound.

NCT ID: NCT00429364 Completed - Marfan Syndrome Clinical Trials

Comparison of Two Medications Aimed at Slowing Aortic Root Enlargement in Individuals With Marfan Syndrome--Pediatric Heart Network

Start date: January 2007
Phase: Phase 3
Study type: Interventional

Marfan syndrome is a hereditary connective tissue disorder. Many individuals with this condition die because of the associated heart and blood vessel abnormalities. This study will compare the effectiveness of two medications, losartan and atenolol, at slowing aortic root enlargement in individuals with Marfan syndrome.

NCT ID: NCT00428948 Completed - Clinical trials for Polycystic Kidney Disease, Autosomal Dominant

Tolvaptan Phase 3 Efficacy and Safety Study in ADPKD

TEMPO3/4
Start date: January 2007
Phase: Phase 3
Study type: Interventional

This study's purpose is to evaluate the long-term safety and efficacy of tolvaptan versus placebo in patients with ADPKD.

NCT ID: NCT00428454 Completed - Clinical trials for Coronary Artery Disease

Sirolimus-eluting vs Zotarolimus-eluting Stents for Chronic Total Coronary Occlusions

Start date: January 2007
Phase: Phase 3
Study type: Interventional

Primary intracoronary stent placement after successfully crossing chronic total coronary occlusions (CTO) decreases the high restenosis rate at long-term follow-up compared with conventional balloon angioplasty. Several studies have shown the efficacy of sirolimus-eluting stents in selected groups of patients. In the PRISON II study we demonstrated that sirolimus-eluting stents were superior to bare metal stents in CTO. In this prospective randomized trial, sirolimus-stent implantation will be compared with zotarolimus-eluting stent implantation for the treatment of chronic total coronary occlusions. A total of 300 patients will be clinically followed up for 1, 6, 12 months, 2, 3, 4, 5 year with angiographic follow-up at 8 months. Quantitative coronary analysis will be performed by an independent core laboratory. The primary end point is in-segment late luminal loss at 8 month angiographic follow-up.

NCT ID: NCT00428220 Completed - Clinical trials for Non-Small Cell Lung Cancer

A Continuation Study Using Sunitinib Malate For Patients Leaving Treatment On A Previous Sunitinib Study.

Start date: July 2007
Phase: N/A
Study type: Interventional

This is a study using sunitinib for patients ending treatment on a previous sunitinib malate protocol to continue to receive sunitinib. The patient must have been enrolled in one of the following studies: A6181030, A6181064, A6181078, A6181087, A6181094, A6181107, A6181108, A6181110, A6181111, A6181112, A6181113, A6181120, A6181126 and A6181170. Other Pfizer sponsored sunitinib studies may be included in the future.

NCT ID: NCT00426803 Completed - Clinical trials for Acquired Bleeding Disorder

Recombinant Factor VIIa in Acute Intracerebral Haemorrhage

Start date: August 2002
Phase: Phase 2
Study type: Interventional

This trial is conducted in North America, Europe, Asia and Oceania. The purpose of this study is to evaluate safety and efficacy of Recombinant Factor VIIa in patients with acute intracerebral bleeding.

NCT ID: NCT00426660 Completed - Clinical trials for Advanced HIV Infection

Expanded Access Program for Maraviroc At Multiple Centers

Start date: February 2007
Phase: Phase 3
Study type: Interventional

To provide access to maraviroc to patients who have limited or no therapeutic treatment options and to collect more safety data in a broader patient population.

NCT ID: NCT00426595 Completed - Clinical trials for Gastreoesophageal Reflux Disease

Pharmacokinetics of Enteral Omeprazole Suspension in Patients With Cerebral Palsy and Mental Retardation

Start date: April 2007
Phase: Phase 2
Study type: Interventional

Gastroesophageal reflux disease and reflux-esophagitis are a major chronic problem in most children with cerebral palsy and mental retardation. Oral administration of enteric-coated formulations of the acid-labile proton pump inhibitor omeprazole is often problematic in these patients who may be suffering from swallowing disorders. A suspension of omeprazole in a sodium bicarbonate solution is often used for administration via the gastrostomy tube. This trial aims to compare the pharmacokinetics of omeprazole administered through the gastrostomy tube as a suspension in pediatric patients with cerebral palsy and mental retardation versus the pharmacokinetics of omeprazole administered as a multi-unit-pellet system (MUPS®). The crossover study will consist of 2 consecutive treatment periods of 14 days.