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NCT ID: NCT00143143 Completed - Epilepsies, Partial Clinical Trials

Pregabalin Open-Label Extension Trial in Patients With Partial Seizures

Start date: September 2001
Phase: Phase 3
Study type: Interventional

The primary purpose of the protocol is to evaluate the long-term safety of pregabalin in patients with partial seizures.

NCT ID: NCT00141245 Completed - Clinical trials for Seizure Disorder, Partial

To Evaluate Long-Term Safety and Efficacy of Pregabalin in Patients With Partial Seizures.

Start date: October 1998
Phase: Phase 3
Study type: Interventional

To evaluate long-term safety and efficacy of pregabalin in patients with partial seizures.

NCT ID: NCT00140543 Completed - Clinical trials for Diabetes Mellitus, Type 1

European Trial of Immunosuppression in SPK Tx

Start date: February 2002
Phase: Phase 3
Study type: Interventional

1. To determine and compare the efficacy of Tacrolimus/Rapa versus Tacrolimus/MMF-based immunosuppression (in conjunction with initial short-term steroids and polyclonal antibody administration) in Type 1-diabetic patients undergoing simultaneous pancreas/kidney allograft transplantation. 2. To evaluate the safety of Tacrolimus/Rapa versus Tacrolimus/MMF in terms of drug-related complications and overimmunosuppression-associated complications, particularly under monitoring of the pharmacokinetic profile of all drugs administered.

NCT ID: NCT00139594 Completed - Bipolar Disorder Clinical Trials

Open Label Extension Study of Licarbazepine in the Treatment of Manic Episodes of Bipolar I Disorder

Start date: December 2004
Phase: Phase 4
Study type: Interventional

This extension study is designed to assess the long-tem tolerability and safety of licarbazepine in patients who completed the 6-week double-blind study CLIC477D2303.

NCT ID: NCT00137189 Completed - Mental Disorders Clinical Trials

Resource-oriented Music Therapy for Psychiatric Patients With Low Therapy Motivation

Start date: April 2005
Phase: N/A
Study type: Interventional

The aim of this study is to examine whether resource-oriented music therapy helps psychiatric patients with low therapy motivation to improve negative symptoms and other health-related outcomes.

NCT ID: NCT00136344 Completed - Endophthalmitis Clinical Trials

Study of Antibiotic Prophylaxis for Endophthalmitis Following Cataract Surgery

Start date: September 2003
Phase: N/A
Study type: Interventional

Cataract is the most important cause of visual impairment and decreased mobility in the elderly. While surgery is usually successful, it is also responsible for permanent loss of vision in up to 0.1% of patients due to severe post-operative infection (endophthalmitis). Because of this risk, surgery is typically performed on one eye at a time leaving the patient with a monocular cataract causing considerable visual impairment with reduction in mobility and quality of life. A second operation is required which often takes place up to one year later. It is not known at present whether the post-operative complication of endophthalmitis can be prevented by perioperative use of antibiotics. This randomised study (masked and placebo-controlled for topical levofloxacin and unmasked for intracameral injection of cefuroxime) sets out to test in 4 groups, each of 8,750 cataract surgery patients, if either topical antibiotic (levofloxacin) perioperatively or an intraocular (intracameral) injection of antibiotic (cefuroxime) at the end of phacoemulsification cataract surgery or the combination provides effective prophylaxis of post-operative infection (endophthalmitis) compared to controls in whom perioperative antibiotics are not used. The result will provide a scientific basis for prophylaxis of infection (endophthalmitis) following cataract surgery in Europe as well as an accurate figure for the incidence of endophthalmitis following phacoemulsification cataract surgery in Europe for the first time.

NCT ID: NCT00134940 Completed - Clinical trials for Coronary Heart Disease

Post-marketing Study to Collect Safety Data in Heart Transplant Patients Receiving Everolimus

Start date: January 2005
Phase: Phase 4
Study type: Observational

The purpose of this observational protocol is to evaluate the use of everolimus in routine clinical practice for heart transplants. Primary outcome measures: incidence of acute rejection episodes Secondary outcomes: safety

NCT ID: NCT00134563 Completed - Multiple Sclerosis Clinical Trials

Study of Teriflunomide in Reducing the Frequency of Relapses and Accumulation of Disability in Patients With Multiple Sclerosis

TEMSO
Start date: September 2004
Phase: Phase 3
Study type: Interventional

The primary objective was to determine the effect of teriflunomide on the frequency of relapses in patients with relapsing multiple sclerosis (MS). Secondary objectives were: - to evaluate the effect of teriflunomide on the accumulation of disability as measured by Expanded Disability Status Scale [EDSS], the burden of disease as measured by Magnetic Resonance Imaging [MRI] and patient-reported fatigue; - to evaluate the safety and tolerability of teriflunomide.

NCT ID: NCT00133250 Completed - Clinical trials for Myocardial Infarction

Value of Abciximab in Patients With AMI Undergoing Primary PCI After Clopidogrel Pretreatment (BRAVE 3)

Start date: June 2003
Phase: Phase 4
Study type: Interventional

The purpose of this study is to assess whether abciximab is associated with additional benefit in patients with AMI treated with PCI after high dose clopidogrel loading.

NCT ID: NCT00132678 Completed - Bipolar Disorder Clinical Trials

A Study of the Safety and Efficacy of Injectable Risperidone in the Prevention of Bipolar Mood Episodes

Start date: February 2005
Phase: Phase 3
Study type: Interventional

The purpose of this study is to determine if risperidone is effective and safe in the prevention of mood episodes in patients with bipolar 1 disorder.