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NCT ID: NCT00269828 Terminated - NSCLC Clinical Trials

A Survival Study for Women With Advanced Lung Cancer Who Have Not Previously Received Chemotherapy.

PIONEER
Start date: December 2005
Phase: Phase 3
Study type: Interventional

This is a randomized, open-label, multinational, phase III study in women with histologically- or cytologically-confirmed advanced NSCLC who are chemotherapy naïve and have PS 2. Study drug will be administered on day 1 of each 21 day cycle

NCT ID: NCT00269516 Completed - Clinical trials for Early Stage Parkinson's Disease

SLV308 for Treatment of Patients With Early Parkinson's Disease

Start date: June 2006
Phase: Phase 3
Study type: Interventional

This study is a multicenter, randomized, double blind, parallel group study of 6 months' treatment with SLV308 administered as a monotherapy in patients with early stage PD. An open label safety extension to this study is planned as a separate protocol for patients who are willing and eligible to participate.

NCT ID: NCT00269048 Completed - Atherosclerosis Clinical Trials

SB-480848 In Subjects With Coronary Heart Disease

Start date: November 2005
Phase: Phase 2
Study type: Interventional

This trial of SB-480848 in approximately 920 subjects with Coronary Heart Disease (CHD) or CHD-risk equivalent will examine whether SB-480848 produces sustained inhibition of plasma Lp-PLA2 activity, explore the effects of SB-480848 on other circulating biomarkers associated with cardiovascular risk, and evaluate the pharmacokinetics, safety and tolerability of SB-480848 over 12 weeks of once-daily oral dosing. Subjects will first be randomized 1:1 to double-blind atorvastatin 20 mg or 80 mg once daily for a minimum of 3 weeks. Subjects will then be randomized 1:1:1:1 to oral doses of SB-480848 40 mg, 80 mg, 160 mg or placebo once daily for 12 weeks. Blood samples will be collected at various timepoints. Vital signs, electrocardiograms, clinical laboratory safety tests and adverse event assessments will be performed to evaluate the safety and tolerability of SB-480848.

NCT ID: NCT00268216 Completed - Clinical trials for Pulmonary Disease, Chronic Obstructive

Survival Of Subjects With Chronic Obstructive Pulmonary Disease (COPD)

Start date: September 2000
Phase: Phase 3
Study type: Interventional

The purpose of this study is to see if fluticasone 500mcg/salmeterol 50mcg can improve the survival of subjects with COPD and also assess the long term safety profile of this drug.

NCT ID: NCT00266747 Completed - Anxiety Disorders Clinical Trials

An Eight-Week Study to Evaluate the Efficacy and Safety of SR58611A in Patients With Generalized Anxiety Disorder

AQUARIUS
Start date: December 2005
Phase: Phase 3
Study type: Interventional

The purpose of the study is to evaluate the efficacy and safety of SR58611A in patients with Generalized Anxiety Disorder. The primary objective is to evaluate the efficacy of a 700 mg dose of SR58611A compared to placebo in patients with generalized anxiety disorder (GAD).The secondary objectives are to evaluate the efficacy of SR58611A on disability and quality of life in patients with GAD and to evaluate safety of SR58611A.

NCT ID: NCT00264667 Completed - Clinical trials for Metabolic Syndrome X

Study In Patients With Dyslipidaemia

Start date: December 2005
Phase: Phase 2
Study type: Interventional

Study in patients with dyslipidaemia.

NCT ID: NCT00264550 Completed - Clinical trials for Rheumatoid Arthritis

An Efficacy and Safety Study of Golimumab in Patients With Active Rheumatoid Arthritis Despite Methotrexate Therapy

GO-FORWARD
Start date: December 2005
Phase: Phase 3
Study type: Interventional

The purpose of this study is to evaluate the efficacy and safety of golimumab, alone or in combination with methotrexate (MTX), as compared to methotrexate alone in rheumatoid arthritis (RA) patients who have active rheumatoid arthritis despite treatment with MTX.

NCT ID: NCT00264537 Completed - Clinical trials for Rheumatoid Arthritis

A Study of the Safety and Efficacy of Golimumab in Subjects With Rheumatoid Arthritis That Are Methotrexate-naive

Start date: December 2005
Phase: Phase 3
Study type: Interventional

The purpose of this study is to evaluate the efficacy and safety of golimumab, alone or in combination with methotrexate, as compared to methotrexate alone in rheumatoid arthritis subjects who have not been previously treated with methotrexate.

NCT ID: NCT00263874 Terminated - Clinical trials for Pulmonary Disease, Chronic Obstructive

Phase 2 Study of the Safety and Efficacy of UK-500,001 in Adult Patients With COPD

Start date: November 2005
Phase: Phase 2
Study type: Interventional

This initial proof of concept, phase II study aims to assess the safety and efficacy of UK-500,001 for the chronic maintenance treatment of adults with Chronic Obstructive Pulmonary Disease.

NCT ID: NCT00263042 Terminated - Clinical trials for Cardiovascular Disease

Comprehensive Rimonabant Evaluation Study of Cardiovascular ENDpoints and Outcomes

CRESCENDO
Start date: December 2005
Phase: Phase 3
Study type: Interventional

The primary objective is to show whether rimonabant reduces the risk of a heart attack (MI), stroke, or death from an MI or stroke in patients with abdominal obesity with other cardiovascular (CV) risk factors. The secondary objective is to show whether rimonabant reduces the risk of MI, stroke, CV death, or CV hospitalization in these patients.