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NCT ID: NCT00920959 Completed - Asthma Clinical Trials

Advair Pediatric Once-Daily

Start date: November 2001
Phase: Phase 3
Study type: Interventional

To demonstrate if once-daily dosing of ADVAIR 100/50 once-daily has superior efficacy and comparable safety compared with FP 100mcg once-daily in pediatric subjects 4 to 11 years of age with asthma.

NCT ID: NCT00919854 Completed - Clinical trials for Human Immunodeficiency Virus 1

A Safety Study to Evaluate the Antiviral Activity of Darunavir in Combination With Ritonavir in HIV 1 Infected Children

Start date: September 2009
Phase: Phase 2
Study type: Interventional

The purpose of this study is to evaluate the pharmacokinetics (what the body does to the medication), safety and antiviral activity to support dose recommendations by body weight of darunavir with low-dose ritonavir (DRV/rtv), in combination with other antiretroviral drugs (ARVs), in treatment-experienced Human immunodeficiency virus 1 (HIV 1) infected children.

NCT ID: NCT00918138 Completed - Type 2 Diabetes Clinical Trials

Study To Evaluate 24 Hour Blood Sugar Control (24-hour Mean Weighted Glucose) In Subjects That Are Taking Saxagliptin 5 mg Added Onto Metformin XR 1500 XR mg Compared To Subjects Taking Metformin XR 1500 mg Up-titrated To Metformin XR 2000 mg

Start date: August 2009
Phase: Phase 3
Study type: Interventional

The purpose of this study was to compare effect of Saxagliptin as add-on to Metformin on 24-hour mean weighted glucose (MWG) to the effect of uptitrating Metformin in subjects with T2DM inadequately controlled on metformin alone.

NCT ID: NCT00917384 Completed - Gastric Cancer Clinical Trials

Study of IMC-1121B (Ramucirumab) With Best Supportive Care in Participants With Gastric Cancer and Adenocarcinoma

Start date: August 2009
Phase: Phase 3
Study type: Interventional

The purpose of this study is to gather information about the use of an investigational drug called Ramucirumab in adenocarcinomas of the stomach or gastroesophageal junction.

NCT ID: NCT00914693 Completed - Contraception Clinical Trials

EU/LA Pearl Index Study - Transdermal Contraceptive Patch

Start date: April 2009
Phase: Phase 3
Study type: Interventional

The aim of the present study is to prove efficacy and safety of a new contraceptive patch.

NCT ID: NCT00911963 Completed - Hepatitis C Clinical Trials

Pharmacokinetics of Multiple Ascending Doses of VCH-222 in Subjects With Chronic Hepatitis C Infection

Start date: April 2009
Phase: Phase 1/Phase 2
Study type: Interventional

The purpose of this study is to assess antiviral activity when administered alone for 3 days or in combination with peginterferon and ribavirin for 12 weeks. This study will also evaluate the safety and tolerability of treatment with VCH-222 when given alone or in combination with peginterferon and ribavirin. The study will also evaluate the pharmacokinetic profile of VCH-222 in HCV infected subjects.

NCT ID: NCT00910429 Completed - Clinical trials for Pulmonary Hypertension

BAY63-2521 - Long-term Extension Study in Patients With Chronic Thromboembolic Pulmonary Hypertension

CHEST-2
Start date: July 1, 2009
Phase: Phase 3
Study type: Interventional

Patients who have completed the 16 weeks treatment of the CHEST-1 trial (study number 11348) will be asked to participate in this long term extension study with BAY63-2521. The aim of the long term study is to collect additional information to evaluate the safety and tolerability of BAY63-2521. Patients will be treated with open label medication on their individual optimal dose between 0,5 mg - 2,5 mg tid.

NCT ID: NCT00909480 Completed - Clinical trials for Diabetes Mellitus, Type 2

Effect of Insulin Detemir and Insulin Glargine on Blood Glucose Control in Subjects With Type 2 Diabetes

EFFICACY
Start date: May 2009
Phase: Phase 4
Study type: Interventional

This trial is conducted in Asia, South America and the United States of America (USA). The aim of this clinical trial is to determine whether two insulin treatments given once daily are equally effective with respect to the blood glucose lowering effect in subjects with type 2 diabetes inadequately controlled on metformin treatment with or without an additional anti-diabetic drug (OAD).

NCT ID: NCT00908752 Completed - Clinical trials for Hepatocellular Carcinoma

Phase III Trans-Arterial Chemo-Embolization (TACE) Adjuvant HCC

BRISK TA
Start date: July 20, 2009
Phase: Phase 3
Study type: Interventional

The purpose of this study is to compare the Overall Survival (OS) of HCC patients who receive brivanib as adjuvant treatments to TACE therapy, with the OS of HCC patients who receive matched placebo with TACE therapy.

NCT ID: NCT00905372 Completed - Alzheimer's Disease Clinical Trials

Effect of LY2062430 on the Progression of Alzheimer's Disease

EXPEDITION
Start date: May 2009
Phase: Phase 3
Study type: Interventional

Alzheimer's disease (AD) is an age-related degenerative disorder of the brain, characterized by progressive decline in cognitive function and ability to perform activities of daily living, and ultimately can lead to death due to complications of the disease. AD is thought to be caused by an excess of A-Beta amyloid, a sticky protein in the brain that forms amyloid plaques. Treatments that slow the synthesis or deposition of A-Beta amyloid, or that increase clearance, might be expected to slow the progression of AD. LY2062430 (solanezumab) is a humanized anti-A Beta peptide immunoglobulin G-1 (IgG1) monoclonal antibody being developed for the treatment of AD. The primary hypothesis being tested is that LY2062430 will slow cognitive and functional decline in AD as compared with placebo. Each patient's participation will last approximately 19 months. Patients taking approved AD medications may participate in this study and continue taking these medications during the study.