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NCT03462277 Clinical Trial

DNA Methylation and Hydroxymethylation Levels in Patients With Coronary Heart Disease

Coronary Heart Disease Clinical Trial

Official title:
DNA Methylation and Hydroxymethylation Levels in Patients With Coronary Heart Disease

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT03462277
Other study ID # 2016-39
Secondary ID
Status Completed
Phase
First received
Last updated
Start date January 1, 2018
Est. completion date October 1, 2018

Study information
Verified date July 2019
Source Chongqing Medical University
Contact n/a
Is FDA regulated No
Health authority
Study type Observational [Patient Registry]

Clinical Trial Summary

The purpose of this trial is to investigate the relationship between DNA methylation and hydroxymethylation and the expression of DNMTs, TET family gene and the degree of coronary heart disease.

Description:

1. To determine the levels of DNA methylation and hydroxymethylation with coronary heart disease.

2. To investigate the relationship between DNA methylation and hydroxymethylation and the degree of coronary atherosclerosis.

Recruitment information / eligibility
Status Completed
Enrollment 200
Est. completion date October 1, 2018
Est. primary completion date August 1, 2018
Accepts healthy volunteers Accepts Healthy Volunteers
Gender All
Age group 65 Years and older
Eligibility Inclusion Criteria:

Male and Female. Patients older than 65 years old who are willing to participate in the study. CHD patients was defined as at least one lesion in a coronary artery or branches in coronary angiograms. Control group was defined as people with negative findings in coronary angiograms.

Exclusion Criteria:

Patients with concurrent infection or any documented inflammatory illness, such as arthritis or connective tissue diseases, or any other malignancy. Patients with a history of cardiomyopathy. Pregnant women. Severe hepatic dysfunction or End-stage renal failure. Uncontrolled hypertension.

Study Design

Related Conditions & MeSH terms

Locations
Country Name City State
China The First Affiliated Hospital of Chongqing Medical University Chongqing

Sponsors (1)
Lead Sponsor Collaborator
Chongqing Medical University

Country where clinical trial is conducted

China, 

Outcome
Type Measure Description Time frame Safety issue
Primary DNA Methylation and Hydroxymethylation Levels Collection of blood samples and measuring the samples by PCR and ELISA 1 month
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