Coronary Heart Disease Clinical Trial
— SPECT MBFOfficial title:
Comparison of Myocardial Blood Flow Measurements With Dedicated Solid State SPECT Camera Imaging and 99mTc-Tetrofosmin Versus PET Imaging and Rubidium-82
NCT number | NCT02280941 |
Other study ID # | 20140589 |
Secondary ID | |
Status | Recruiting |
Phase | N/A |
First received | |
Last updated | |
Start date | October 2014 |
Est. completion date | October 2022 |
This study is being done to compare the blood flow measurements obtained with the SPECT and PET imaging scans. Measurements such as myocardial blood flow (MBF) and myocardial flow reserve (MFR) are analyzed on PET scans. These measurements give the doctors more precise information in diagnosing heart problems. SPECT scans, with new camera technology and computer software, now have the potential to also give this additional information. The study is investigating how well the blood flow measurements from SPECT compared to PET.
Status | Recruiting |
Enrollment | 90 |
Est. completion date | October 2022 |
Est. primary completion date | August 2022 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 18 Years and older |
Eligibility | Inclusion Criteria: For all participants - Age = 18 years old - BMI = 40 kg/m2 - Able and willing to comply with the study procedures - Written informed consent Participants with intermediate to high probability of CAD - Suspected or known CAD on a stable medication regime. Healthy volunteers without known heart disease - Low risk of CAD (ACC Guidelines Pre-test Probability of Coronary Disease by Symptoms, Gender and Age) Exclusion Criteria: - History or risk of severe bradycardia (heart rate < 50 beats per minute) not related to chronotropic drugs - Known second- or third-degree AV block without pacemaker - Dyspnea (NYHA III/IV), wheezing asthma or COPD - Coronary artery bypass graft (CABG) surgery within 60 days prior to screening or at any time after consent - Percutaneous coronary intervention (PCI) within 30 days prior to screening or at any time following consent - Acute myocardial infarction or acute coronary syndrome within 60 days prior to screening or at any time following consent - Recent use of dipyridamole, dipyridamole-containing medications (e.g. Aggrenox) - Known hypersensitivity to dipyridamole - Breastfeeding or pregnancy - Claustrophobia or inability to lie still in a supine position - Unwillingness or inability to provide informed consent |
Country | Name | City | State |
---|---|---|---|
Canada | University of Ottawa Heart Institute | Ottawa | Ontario |
Lead Sponsor | Collaborator |
---|---|
Ottawa Heart Institute Research Corporation | GE Healthcare |
Canada,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Correlation | The correlation of global and regional myocardial blood flow (MBF) measurements and calculated myocardial flow reserve (MFR) using single photon emission computed tomography (SPECT) and 99mTc-tetrofosmin (99mTc) to positron emission tomography (PET) and Rubidium-82 (Rb-82) will be determined. | 3 years | |
Primary | Reproducibility | The reproducibility of global and regional myocardial blood flow (MBF) measurements and calculated myocardial flow reserve (MFR) using single photon emission computed tomography (SPECT) will be determined. | 3 years |
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