Coronary Artery Disease Clinical Trial
Official title:
Ranolazine, Ethnicity and the Metabolic Syndrome - REMS Study
The purpose of this study is to measure the effect of ranolazine on ETT (exercise treadmill test) exercise duration in four ethnic subgroups with established coronary artery disease and risk factor(s) for the metabolic syndrome: Caucasian, African American, Southeast Asian and East Indian.
Studies have shown that various ethnic subgroups are at differential risk for both the
development and progression of coronary artery disease. The East Indian population is one of
the highest risk populations for coronary artery disease. Much of this increased risk is
driven by the development and progression of diabetes.
Recent studies have shown that ranolazine has a favorable effect on glycemic control. In
addition, it is an effective antianginal and antiarrhythmic agent.
The investigators propose a pilot study look at the safety, tolerability and efficacy of
this agent in patients with established coronary artery disease (CAD) and risk factors for
the metabolic syndrome from various ethnic backgrounds. In particular the investigators will
focus on the Caucasian, African American, Southeast Asian and East Indian population.
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Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
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