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NCT00693537 Clinical Trial

Exercise Training Improves Coronary Endothelial Dysfunction in Diabetes Mellitus Type 2 and Coronary Artery Disease

Coronary Artery Disease Clinical Trial

Official title:
Long- But Not Short-term Exercise Training Improves Coronary Endothelial Dysfunction in Diabetes Mellitus Type 2 and Coronary Artery Disease

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT00693537
Other study ID # UISM-2-2008
Secondary ID
Status Completed
Phase Phase 4
First received
Last updated

Study information
Verified date June 2008
Source Paracelsus Medical University
Contact n/a
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

Patients with type 2 diabetes mellitus suffer from accelerated coronary artery disease. We will assess the effects of exercise training on coronary endothelial function, vascular structure, and inflammation both in serum and skeletal muscle biopsies, as well as expression of diabetes candidate genes.

Recruitment information / eligibility
Status Completed
Enrollment 0
Est. completion date
Est. primary completion date
Accepts healthy volunteers No
Gender All
Age group 50 Years to 80 Years
Eligibility Inclusion Criteria:

- written informed consent

- preserved left ventricular function (left ventricular ejection fraction = 50%)

- a physical work capacity = 50 W

- at least one significant coronary stenosis > 50%, whereas either the left anterior descending (LAD) or circumflex artery (RCX) has to be free from disease or stenoses = 25% for the assessment of intracoronary flow measurements

Exclusion Criteria:

- diseases further affecting endothelial function

- untreated hypertension (systolic blood pressure > 160 mm Hg or a diastolic blood pressure of > 90 mm Hg)

- cigarette smoking during the previous six months

- LDL-cholesterol > 4.3 mmol/l

- ventricular tachyarrhythmias

- chronic obstructive pulmonary disease

- severe renal or hepatic dysfunction

- valvular heart disease

- myocardial infarction within the previous 4 weeks

Study Design

Related Conditions & MeSH terms

Intervention

Behavioral:
• Exercise training
4 weeks in-hospital exercise training (6x15 min bicycle/day, 5 days/week) followed by a 5 months ambulatory exercise program (30 min ergometer/day, 5 days/week, plus 1h group exercise/week)

Locations
Country Name City State
Austria University Institute of Sports Medicine, Prevention and Rehabilitation Salzburg

Sponsors (1)
Lead Sponsor Collaborator
Paracelsus Medical University

Country where clinical trial is conducted

Austria, 

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