C1q/TNF-related Proteins in Coronary Artery Disease

Coronary Artery Disease (CAD) Clinical Trial

Official title:

C1q/TNF-related Proteins in Coronary Artery Disease

Clinical Trial Details — Status: Terminated

Administrative data

• NCT number: NCT02083146
• Other study ID #: CAD(CTRP)
• Status: Terminated
• First received: March 7, 2014
• Last updated: March 17, 2018
• Start date: March 2011
• Est. completion date: February 2016

Study information

• Verified date: March 2018
• Source: Korea University
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Now, adipose tissue is established as an active endocrine organ that controls systemic energy homeostasis by secretion of adipokines. Recently, members of the C1q/tumor necrosis factor-related protein (CTRP) family have been reported to share structural homology with adiponectin. To date, 15 CTRP family members have been found that might play major roles in metabolism and inflammation. The investigators tried to clarify the relationship between CTRP family and coronary artery disease (CAD) in Korean men and women.

Description:

Adipose tissue secretes various kinds of bioactive molecules termed adipokines which contribute to the development of obesity-related disorders including cardiovascular disease (CVD). Adiponectin is the insulin-sensitizing adipokine with anti-inflammatory and anti-atherogenic properties. Hypoadiponectinemia has been associated with an increased risk of coronary artery disease (CAD) in several though not all studies. Recently, a new family of secreted proteins, C1q/TNF-related protein (CTRP), was cloned on the basis of sequence homology with adiponectin. This family of adiponectin paralogs might have pivotal implications in energy homeostasis and obesity-related inflammation. Each CTRP family member has its own unique tissue expression profile and function in regulating glucose and/or fat metabolism. In the present study, we evaluated the role of CTRP in patients with CAD and investigated whether CTRP family is significantly associated with CAD prevalence after adjustment for well-known CAD risk factors.

Recruitment information / eligibility

• Status: Terminated
• Enrollment: 362
• Est. completion date: February 2016
• Est. primary completion date: December 2012
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 20 Years to 80 Years

Eligibility

Inclusion Criteria:

• 20<age<80

• History of stable angina, unstable angina, or acute myocardial infarction

Exclusion Criteria:

• a history of diabetes

• stage 2 hypertension

• malignancy

• severe renal or hepatic disease

Related Conditions & MeSH terms

• Coronary Artery Disease
• Coronary Artery Disease (CAD)
• Coronary Disease
• Myocardial Ischemia

Locations

Country	Name	City	State
Korea, Republic of	Korea Univ. Guro Hospital	Seoul

Sponsors (1)

Lead Sponsor	Collaborator
Korea University

Country where clinical trial is conducted

Korea, Republic of, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	serum concentration of CTRP-1,3, or 9 in the subjects with/without CAD	compare serum concentration of CTRP-1,3 or 9 between CAD patients and normal group	at enrollment
Secondary	The relationships of serum CTRPs/adiponectin levels with cardiometabolic risk profiles	find the correlation of CTRPs and adiponection with cardiometabolic risk	at enrollment