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Clinical Trial Summary

To evaluate the effect of evolocumab on fibrous cap thickness (FCT) in subjects with non-ST-elevation acute coronary syndrome (NSTE-ACS) who are taking maximally tolerated statin therapy.

Clinical Trial Description

This study seeks to identify morphologic changes, such as increase in fibrous cap thickness (FCT), in atherosclerotic plaques associated with treatment with evolocumab and maximally tolerated statin therapy with or without additional lipid-modifying medication in patients presenting with non-ST-segment elevation (NSTE)-ACS using optical coherence tomography (OCT;primary, secondary, and exploratory endpoints) and intravascular ultrasound (IVUS; exploratory endpoints only) ;

Study Design

Related Conditions & MeSH terms

NCT number NCT03570697
Study type Interventional
Source Amgen
Contact Amgen Call Center
Phone 866-572-6436
Status Recruiting
Phase Phase 3
Start date November 19, 2018
Completion date June 8, 2021

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