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Cirrhosis clinical trials

View clinical trials related to Cirrhosis.

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NCT ID: NCT06420791 Completed - Clinical trials for Hepatocellular Carcinoma

The Dual Impact of Cirrhosis on Transplantation for Hepatocellular Carcinomaļ¼ša Two-center Retrospective Cohort Study in China

Start date: February 28, 2024
Phase:
Study type: Observational

Background: This study aims to investigate the correlation between cirrhosis and hepatocellular carcinoma (HCC) recurrence after Liver Transplantation. Methods: The study retrospectively collected data enrolled from 519 HCC patients who underwent liver transplantation from two center(the First Affiliated Hospital, Zhejiang University School of Medicine and Shulan (Hangzhou) Hospital, January 2015 to December 2020), Based on important variables, 1:3 propensity score matching (PSM) were performed respectively.

NCT ID: NCT05835180 Completed - Cirrhosis Clinical Trials

A Phase I Pharmacokinetic Study of TVB-2640 (Denifanstat) in Subjects With Mild, Moderate, or Severe Hepatic Impairment Compared to Subjects With Normal Hepatic Function

Start date: May 1, 2023
Phase: Phase 1
Study type: Interventional

The goal of this phase 1 study is to assess the pharmacokinetics, safety and tolerability following multiple oral doses of TVB-2640 in subjects with mild, moderate, or severe hepatic impairment compared to healthy subjects with normal hepatic function.

NCT ID: NCT05724485 Completed - Quality of Life Clinical Trials

Effect of Branched-chain Amino Acids (BCAA) to Muscle Cramps in Patients With Cirrhosis

Start date: April 1, 2023
Phase: Phase 4
Study type: Interventional

The goal of this randomized controlled trial is to compare the efficacy and safety of branched-chain amino acids (BCAA) versus placebo for treating muscle cramps in cirrhotic patients. The main questions it aims to answer are: - Compared the effect of BCAA versus placebo on muscle cramp frequency in cirrhotic patients - Compared the effect of BCAA versus placebo on muscle cramp duration and severity in cirrhotic patients - Compared the effect of BCAA versus placebo on quality of life in cirrhotic patients with muscle cramps Participants with cirrhosis who have experienced muscle cramps at least once per week will be randomized to receive either a placebo or 12.45 grams of BCAA orally per day for 12 weeks.

NCT ID: NCT05689268 Completed - Cirrhosis Clinical Trials

EUS-PPG vs HVPG in Portal Hypertension

GRAPE
Start date: February 1, 2023
Phase: N/A
Study type: Interventional

The objective of this study is to evaluate the correlation of the calculated portal pressure gradient (PPG) obtained by direct portal and hepatic pressure measurements with a conventional 22 G needle guided by EUS and indirect portal vein pressure measurements using the interventional radiology based hepatic venous pressure gradient (HVPG) procedure.

NCT ID: NCT05545670 Completed - Cirrhosis Clinical Trials

Allopurinol to Prevent Cirrhosis Related Morbidities

Start date: June 15, 2022
Phase: Phase 2/Phase 3
Study type: Interventional

The study aims to compare the potential benefit of allopurinol in reducing the risk of developing cirrhosis-related complications, delaying the onset of hepatocellular carcinoma, and improving survival. Furthermore, the study aims to evaluate their impact on parents' related quality of life

NCT ID: NCT05376488 Completed - Cirrhosis Clinical Trials

Effect of Brief Dietary Intervention on Ammonia Levels

Start date: May 1, 2022
Phase: N/A
Study type: Interventional

Study the impact of differing meal contents on venous ammonia levels over time in patients with cirrhosis. Patients will be given specific meals and venous ammonia analyzed over time after those meals. The subjects will also provide stool for microbiome and serum, urine and plasma for metabolomics during this one-time study. Total duration=4 hours

NCT ID: NCT05309200 Completed - Acute Kidney Injury Clinical Trials

A Study of OCE-205 in Participants With Cirrhosis With Ascites Who Developed Hepatorenal Syndrome-Acute Kidney Injury

Start date: April 28, 2022
Phase: Phase 2
Study type: Interventional

OCE-205 is being tested to treat participants who have developed Hepatorenal Syndrome-Acute Kidney Injury as a complication of cirrhosis with ascites. The study aims are to evaluate the safety and efficacy of OCE-205 at various doses. Participants will receive treatment by intravenous infusion. Participants will continue with this treatment until participants meets primary endpoint or any discontinuation criteria.

NCT ID: NCT05304455 Completed - Cirrhosis Clinical Trials

Apixaban Prevents Portal Vein Thrombosis After Laparoscopic Splenectomy and Azygoportal Disconnection

ESAPT
Start date: April 1, 2022
Phase: N/A
Study type: Interventional

The purpose of this study is to determine whether Apixaban is effective and safe in Prevention of Portal Vein Thrombosis in Liver Cirrhotic Patients after Laparoscopic Splenectomy and Azygoportal Disconnection

NCT ID: NCT05300516 Completed - Hypertension Clinical Trials

Vagus Nerve-guided Robotic-assisted Splenectomy and Azygoportal Disconnection

VNRSD
Start date: April 1, 2022
Phase: N/A
Study type: Interventional

This study aimed to evaluate whether vagus nerve-guided robotic-assisted splenectomy and azygoportal disconnection is effective and safe, and to determine whether a reduction in the incidence of postoperative complications of the digestive system improves postoperative quality of life compared with conventional robotic-assisted splenectomy and azygoportal disconnection.

NCT ID: NCT05231772 Completed - Cirrhosis Clinical Trials

Probiotics and Hemodynamic Changes in Cirrhosis

PrBHCCir
Start date: March 1, 2021
Phase: N/A
Study type: Interventional

This is a single-center blinded randomized interventional placebo-controlled study of the effect of probiotics on hemodynamic parameters and liver function in cirrhosis.