Cardiovascular Diseases Clinical Trial
To determine whether deficient vagal antagonism of sympathetic nervous system (SNS) actions on the heart contributed to increased coronary heart disease risk in hostile persons.
DESIGN NARRATIVE:
Sophisticated electrophysiologic monitoring approaches were used to: 1) show greater
sensitivity in nonhostile young men to T-wave attenuation effects of isoproterenol infusion
following vagal blockade; 2) show that vagal enhancement reduced and shortened the T-wave
attenuation effects of isoproterenol infusion more in hostile young men; 3) evaluate these
effects of vagal blockage and enhancement in middle-aged men and in young and middle-aged
women; and 4) relate the T-wave effects in these studies to other measures of vagal tone and
other biobehavioral mechanisms of coronary-prone behavior.
Four studies were conducted in normal young and middle-aged men and women selected as high
and low on hostility, evaluating vagal tone measures and effects of isoproterenol infusion
on EKG T-wave and ST response after pretreatment with saline, neostigmine, and atropine.
Demonstration that hostility was associated with deficient vagal anatagonism of SNS effects
on the heart, especially in middle-aged as compared to younger persons, suggested that
diminished vagal tone was one pathway whereby high hostility contributed to increased CHD
risk. Clinical studies were then conducted to determine whether weaker vagal tone predicted
increased myocardial ischemia and/or poorer outcomes in coronary heart disease patients.
The study completion date listed in this record was obtained from the "End Date" entered in
the Protocol Registration and Results System (PRS) record.
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