Heart Failure Clinical Trial
Official title:
Importance of Left Ventricular Pacing Site in Biventricular Resynchronization Therapy for Severe Heart Failure
Cardiac resynchronization therapy has been shown to be effective in reducing symptoms and mortality in heart failure patients. However, very few is known about the importance of the left ventricular pacing site. We study in a random order 11 different left ventricular pacing sites and compare their hemodynamics using pressure-volume catheters. The consequences on the surface ECG are also assessed.
Background. Cardiac resynchronization therapy has been shown to be effective in reducing
symptoms and mortality in heart failure patients. However, very few is known about the
importance of the left ventricular pacing site.
Design. Single-blind, monocentric, randomized cross-over study comparing 11 left ventricular
pacing sites in a random order.
Intervention. Left ventricular DDD pacing on 11 ventricular sites, prior to the
implantation. At each pacing site, a control hemodynamics will be obtained in AAI pacing at
the same pacing rate. At each pacing site, 2 AV delays, a short and a long one, will be
assessed.
Eligibility criteria. Patients referred for cardiac resynchronization therapy for heart
failure
Outcomes. Hemodynamic measures using pressure-volume catheters.
;
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Crossover Assignment, Masking: Single Blind, Primary Purpose: Treatment
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