Partial Breast Re-irradiation in Women in Women With Locally Recurrent Breast Cancer Previously Treated With Conservative Surgery and Whole Breast Irradiation — PBReI  

Breast Cancer Clinical Trial

Official title: Partial Breast Re-irradiation in Women With Locally Recurrent Breast Cancer Previously Treated With Conservative Surgery and Whole Breast Irradiation: A Prospective Phase II Clinical Study

Status Recruiting

Clinical Trial Summary

A prospective study of partial breast re-irradiation in patients with local recurrence of breast cancer

Clinical Trial Description

Breast cancer is the leading type of cancer in women worldwide. Although advances in treatment have led to an overall reduction in breast cancer mortality, survivors continue to have an ongoing risk of disease recurrence. For women who experience breast recurrence, mastectomy has historically been the only treatment approach offered. However, it has been associated with negative health outcomes, including reduced quality of life, depression and anxiety, and impaired sexual functioning. As a result, there is increasing interest to identify treatment options that include breast preservation. Breast-conserving surgery followed by re-irradiation with partial breast irradiation has recently been found to be a safe alternative to mastectomy for women who have undergone prior whole breast radiation. ;

Related Conditions & MeSH terms

• Breast Cancer
• Breast Neoplasms
• Recurrence
• Recurrent

• NCT number: NCT05772390
• Study type: Interventional
• Source: Istituto Scientifico Romagnolo per lo Studio e la cura dei Tumori
• Contact: Oriana Nanni
• Phone: +390543739266
• Email: oriana.nanni@irst.emr.it
• Status: Recruiting
• Phase: Phase 2
• Start date: March 31, 2023
• Completion date: March 2032