Breast Cancer Clinical Trial
Official title:
Prevention of Obesity-related Cancers: Setting up of a Multi-Cancer Education and Prevention Program in Hong Kong
Obesity could increase the risk of many chronic diseases, including hypertension,
cardiovascular diseases, high lipid level, diabetes, stroke, endometrial cancer and certain
types of cancer which could benefit by secondary prevention through screening programs. The
World Cancer Research Fund of the American Institute for Cancer Research has reviewed all the
studies about the link between obesity and cancer. Studies shown that obesity is an
independent risk factor for colorectal, breast and prostate cancer. These three cancers (will
be named as "obesity-related cancers" thereafter) demonstrate a rapidly increasing trend of
incidence in Asia in the past decade.
Among Chinese adults of Hong Kong in 2014, 39% were overweight or obese (compared with 20.9%
reported in European adults in the same year) and up to 69.7% reported that they did not
perform any measures to achieve optimal weight control. Men (49.6%) had a higher proportion
of overweight or obesity than females (29.5%). Adults who are aged 45-54 had the highest rate
(50.5%) of overweight or obesity than other age groups. In addition, there were 62.5% whose
physical activity level did not meet the recommendations from the World Health Organization
(WHO). Only 18.7% consumed at least 5 portions of fruit and vegetables per day; yet about 30%
were alcoholic drinkers; and more than 10% were daily or occasional smoker. These figures
imply that the incidence of obesity and obesity-related cancers will further escalate - and
urgent actions at the community level are needed to combat the rising incidence and mortality
of these conditions.
According to Hong Kong Cancer Registry, the discrepancy between the number of new cases
(incidence) and number of deaths (mortality) is much higher for colorectal, breast and
prostate cancer as compared to other cancers. It is well recognized that screening could
effectively reduce mortality for these three obesity-related cancers when they are detected
at an earlier stage.
The concept of a one-stop approach to screen for multiple cancers was found to be feasible,
with an ability to detect a wide range of neoplastic lesions at an early stage. In the recent
decade, there are also emerging centres that have been established as multi-cancer screening
clinics worldwide. Nevertheless, there is a scarcity of studies that have highlighted the
outcomes of these multi-cancer screening programs.
Status | Recruiting |
Enrollment | 10000 |
Est. completion date | December 31, 2023 |
Est. primary completion date | December 31, 2022 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 40 Years to 75 Years |
Eligibility |
Inclusion Criteria: - Age 40 to 75 years depending on risk factor(s); - Measured BMI = 25 kg/m2; or waist circumference >80cm [women] or >90 cm [men]; and - Absence of existing or previous symptoms suggestive of CRC and breast cancer Exclusion Criteria: - Having received updated CRC screening tests (FIT in the past 2 year; flexible sigmoidoscopy in the past 5 years; colonoscopy in the past 10 years); - Having received updated prostate or breast screening test in the past 2 years; - Having personal of CRC, prostate or breast cancers; - Having personal history of colonic adenoma, diverticular disease or inflammatory bowel disease; - Having medical conditions which were contraindications for colonoscopy, like cardiopulmonary insufficiency and the use of double antiplatelets, etc.; and - Having medical conditions and disabling conditions with limited life expectancy |
Country | Name | City | State |
---|---|---|---|
Hong Kong | Lek Yuen Health Centre | Hong Kong |
Lead Sponsor | Collaborator |
---|---|
Chinese University of Hong Kong |
Hong Kong,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Colorectal cancer detection rate | Evaluate the effectiveness of CRC screening in a one-stop community based obesity-related cancers screening program | 5 Years | |
Primary | Prostate cancer detection rate | Evaluate the effectiveness of prostate cancer screening in a one-stop community based obesity-related cancers screening program | 5 Years | |
Primary | Breast cancer detection rate | Evaluate the effectiveness of breast cancer screening in a one-stop community based obesity-related cancers screening program | 5 Years |
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