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Clinical Trial Summary

Evaluation effectiveness and safety of TMS in subjects with catatonia


Clinical Trial Description

Non-pharmacological strategies for influencing brain structures show great potential, particularly transcranial magnetic stimulation (TMS), which allows targeting specific areas of the brain and activating neuroplastic processes that contribute to the restoration of lost functions. According to study hypothesis, therapy for catatonia is possible through the stimulation of the dorsolateral prefrontal cortex (DLPFC), given its accessibility and role in the syndrome's development because. It has been established that a key process in the pathogenesis of catatonia is the disruption of the structural-functional connectivity and activity of several regions within the fronto-temporal network The design of the study involves following stages: - diagnostic stage and randomization - two personalized stimulation protocols (high- and low-frequency delivery of magnetic pulses) with placebo control - initial analysis of the effectiveness of protocols after 10 sessions of stimulation, followed by the transfer of all patients, including the placebo group to the most effective protocol. - the stage of active neuromodulation of 20 sessions (4 weeks) according to the protocol of effective stimulation regiment - final analysis of the effectiveness after 20 sessions of TMS, as well as after 1 and 6 months ;


Study Design


Related Conditions & MeSH terms


NCT number NCT06176456
Study type Interventional
Source Moscow Psychiatric Hospital No. 1 Named after N.A. Alexeev
Contact Natalia Zakharova, MD, PhD
Phone +7 906 052 02 57
Email nataliza80@gmail.com
Status Recruiting
Phase N/A
Start date November 1, 2023
Completion date November 1, 2024

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