Hypertension Clinical Trial
Official title:
Effects of Feet Mechanical Stimulation on the Inflammatory State and Cardiovascular Autonomic Profile in Patients With Parkinson's Disease
In the present study, investigators test the hypothesis that a controlled mechanical pressure applied on specific sites of both fore-feet (ES) can reduce the inflammatory state and arterial blood pressure in patients with Parkinson's Disease by increasing the overall parasympathetic activity and reducing vascular sympathetic modulation.
Neuroinflammation may contribute to the cascade of events leading to neuronal loss in
Parkinson's disease (PD) thus facilitating motor and autonomic impairment. A link between
autonomic function and chronic and acute inflammation has been previously described.
Specifically, active inflammatory state was associated with an overall increased sympathetic
tone, whereas the parasympathetic cholinergic activation seemed to promote a decrease of
inflammatory compounds in inflamed tissues. In addition, a functional link between peripheral
sensory afferents and autonomic control has been reported. In a recent study it was observed
that in PD patients a somatosensory activation by mechanical stimulation of specific sites of
the fore-foot (effective stimulus, ES), improved gait, increased cardiac vagal modulation and
decreased vascular sympathetic activity at rest. This latter effect was associated with a
decline in arterial blood pressure values.
The present study is aimed at:
- Addressing the magnitude of the inflammatory state in PD patients.
- Testing the hypothesis that a change in the autonomic profile of PD patients induced by
ES, consistent with cardiovascular increased parasympathetic and decreased sympathetic
activities, may promote an overall reduction of the PD inflammatory state.
;
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