Atherosclerosis, Coronary Clinical Trial
Official title:
Comprehensive Evaluation of Ischemic Heart Disease Using MRI
The purpose of the study is to assess the diagnostic performance of fully automated motion corrected (MC) first pass myocardial perfusion MRI, compared to the original non-corrected first pass myocardial perfusion images in a cohort of patients with suspected ischemic heart disease, using coronary angiography as the reference standard. It is expected that this improved comprehensive protocol for cardiac MRI be accurate at detecting significant coronary artery disease and may obviate the need for other more expensive and invasive diagnostic tests currently used.
Coronary heart disease is the leading cause of death and disability in the US, accounting
for about one-third of all deaths in subjects over age 35.
With the development of newer Magnetic Resonance Imaging (MRI) techniques, such as faster
pulse sequences and parallel imaging, cardiac MRI has become a routine tool for the
evaluation and detection of myocardial ischemic disease. First pass myocardial perfusion
(FPMP) using MRI is increasingly being used to assess ischemic heart disease. MRI offers the
advantages of spatial resolution sufficient to differentiate between subendocardial and
subepicardial perfusion; shorter examination time and also lack of ionizing radiation. Left
ventricle cine gradient echo imaging can be used to assess regional ventricular function.
Left ventricular myocardial viability can also be easily assessed at the same time in order
to determine the amount of viable left ventricular myocardium and the percentage of
irreversibly scarred myocardium by delayed enhanced images. Viability imaging is usually
added to the perfusion protocol to increase specificity by allowing detection of fixed
perfusion defects, which represent scar. The ultimate cardiac MRI protocol would be to
combine both of these imaging strategies with a reliable and accurate coronary Magnetic
Resonance Angiography(MRA) technique, such that obstructive coronary artery disease could be
evaluated comprehensively at the same time. If all of these techniques can be combined
together in a single study, it may be feasible to finally achieve a "one stop shop" for
cardiac Magnetic Resonance Imaging.
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Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Diagnostic
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