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Clinical Trial Summary

The purpose of this study is to develop and evaluate the usefulness of hyperpolarized (HP) 129Xe gas MRI for regional assessment of pulmonary function.


Clinical Trial Description

This is an unblinded, open-label study with ~160 subjects with diagnosed pulmonary disease and ~100 healthy controls. Subjects to be enrolled will include males and females 18-80 years old. Evaluation will be on an outpatient basis. Imaging will be done on a single day and will involve administration of up to four 1-liter doses of HP 129Xe plus one 129Xe calibration dose (~300-400mL HP 129Xe). In addition to 129Xe MRI, a series of anatomical conventional 1H MR images will be collected including a localizer scan, breath-hold spin echo image, and breath-hold steady-state free precession image to highlight the vasculature. All subjects will be evaluated at one center: The University of Kansas Medical Center, KS USA. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT04624490
Study type Interventional
Source University of Kansas Medical Center
Contact Cristal Monge
Phone 913-945-9399
Email chernandez@kumc.edu
Status Recruiting
Phase Phase 1
Start date November 2, 2020
Completion date October 26, 2026

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