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Aspiration Pneumonia clinical trials

View clinical trials related to Aspiration Pneumonia.

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NCT ID: NCT06395740 Recruiting - Clinical trials for Aspiration Pneumonia

Aspiration Pneumonia in Cerebrovascular Stroke Patients Suffering From Bulbar Palsy

TPN
Start date: May 5, 2024
Phase: Phase 4
Study type: Interventional

One of the most serious complications in the critically ill patient complaining of bulbar palsy is aspiration pneumonia. These patients are scheduled for nasogastric tube feeding trying to avoid recurrent aspiration and subsequent aspiration pneumonia. Even though, the risk of aspiration is still present. Putting a total parenteral nutrition regimen for these patients is a supposed strategy to avoid aspiration pneumonia till recovery from bulbar palsy or planning for tracheostomy and or feeding gastrostomy.

NCT ID: NCT06164639 Enrolling by invitation - ARDS, Human Clinical Trials

Potential Biomarkers for Reflux Aspiration-induced Lung Injury.

Start date: November 28, 2023
Phase:
Study type: Observational [Patient Registry]

There is limited research on aspiration pneumonia-induced ARDS (Acute Respiratory Distress Syndrome), and currently there is a lack of studies on corresponding biomarkers and pathogenic mechanisms. We hypothesize that pH and amylase in BAL (Bronchoalveolar Lavage) may serve as candidate biomarkers for inhalation-induced ARDS, while changes in different cytokines may provide clinical evidence for studying its pathogenic mechanisms.

NCT ID: NCT05810688 Recruiting - Clinical trials for Aspiration Pneumonia

Eating Rehabilitation Training for Timely Removal of Nasogastric Tube in Elderly Patients

Start date: February 21, 2023
Phase: N/A
Study type: Interventional

Aspiration pneumonia is a common complication in senior patients with high morbidity and mortality rate. The decline of physical function among elders can easily lead to swallowing disorders, and nasogastric (NG) tube insertion is an emergency medical treatment that provides patients with adequate hydration and nutrition. However, NG is easily dislodged after a long duration of placement; furthermore, lacking accurate feeding skills could also lead to aspiration pneumonia.

NCT ID: NCT05674643 Recruiting - Fasting Clinical Trials

Gastric Assessment of Pediatric Patients Undergoing Surgery

Start date: February 1, 2023
Phase:
Study type: Observational

The goal of this pilot prospective cohort study is to examine the reproducibility of gastric volume and emptying as measured by gastric ultrasound and its correlation to a gold-standard test for gastric emptying in the perioperative period in pediatric patients. The main questions it aims to answer are: - What is the reliability (inter-rater variability between expert and novice assessors, and intra-rater variability) of a) the gastric antral cross-sectional area (CSA) and b) gastric volume using the Perlas US qualitative grading assessment, measured by using an ultrasound device in pediatric patients undergoing general anesthesia for elective surgery? - What is the correlation between ultrasound assessment of gastric emptying by the antral-CSA and gastric emptying determined by the acetaminophen absorption test (AAT), the gold standard? The study will include two cohorts. Cohort assignment will be based on age and anesthesia induction plan. Subjects >7yrs of age and expected to get an IV induction will be assigned to Cohort #1. Subjects <7yrs of age and not expected to get an IV induction will be assigned to Cohort #2. - Cohort 1 will include abdominal ultrasound for gastric assessment AND the acetaminophen absorption test which includes administering enteral acetaminophen (tylenol) with 6 oz of water and drawing of blood samples through a peripheral intravenous line. - Cohort 2 will include subjects for whom a peripheral intravenous line placement is not part of routine pre-operative care. Procedures for Cohort 2 will include abdominal ultrasound only in the pre-op area (no tylenol). This cohort is included to examine the reliability of measurements across age groups.

NCT ID: NCT05526105 Recruiting - Surgery Clinical Trials

Gastric US in ICU Patient

Start date: February 3, 2023
Phase: N/A
Study type: Interventional

This is a case series study using gastric ultrasound in critically ill patients to quantify gastric residual volumes to compare the efficacy of different NPO protocols.

NCT ID: NCT05455359 Not yet recruiting - Clinical trials for Gastro Esophageal Reflux

Gastrointestinal Dysmotility on Aspiration Risk

Start date: July 18, 2022
Phase: Phase 4
Study type: Interventional

The hypothesis of this study is that esophageal and gastric dysmotility increase the risk of developing aspiration-associated symptoms in children with neurologic impairment. The investigators are conducting a ten week cross over study comparing prucalopride to famotidine for the treatment of aspiration-associated symptoms.

NCT ID: NCT05290844 Completed - Pediatric Clinical Trials

The Cricoid Pressure in Pediatric Patients

Start date: April 5, 2022
Phase: N/A
Study type: Interventional

Because the cricoid force in children has not been quantified, clinicians wrongly used the 'adult' force. it has been found that the use of the adult force can result in compression and distortion of the child's airway and can lead to airway obstruction and difficult intubation. Based on known measurements of the cricoid surface area in children, the theoretical forces necessary to occlude the esophageal entrance have been calculated . These forces were found to be much less than the recommended adult force and much less than the forces that distort the airway as reported previously. Based on these theoretical calculations, the current study was performed to determine the effective cricoid force for pediatric groups (group 1 and group 2).

NCT ID: NCT05098808 Completed - Stroke Clinical Trials

Artificial Intelligence in Diagnosing Dysphagia Patients

Start date: September 1, 2019
Phase:
Study type: Observational [Patient Registry]

In this prospective study we extracted acoustic parameters using PRAAT from patient's attempt to phonate during the clinical evaluation using a digital smart device. From these parameters we attempted (1) to define which of the PRAAT acoustic features best help to discriminate patients with dysphagia (2) to develop algorithms using sophisticated ML techniques that best classify those i) with dysphagia and those ii ) at high risk of respiratory complications due to poor cough force.

NCT ID: NCT05079620 Recruiting - Aspiration Clinical Trials

Early Antibiotics After Aspiration in ICU Patients

Start date: November 30, 2021
Phase: Phase 4
Study type: Interventional

The purpose of this study is to evaluate the use of early antibiotics in ICU patients who appear to have aspirated, to help determine whether this improves outcomes by reducing the later incidence of pneumonia and other negative consequences.

NCT ID: NCT04873297 Completed - Acute Stroke Clinical Trials

Metoclopramide vs Placebo for Prevention of Pneumonia in Acute Stroke

Start date: May 2, 2021
Phase: Phase 4
Study type: Interventional

Pneumonia is a major cause of mortality and morbidity in patients with acute stroke fed via nasogastric tubes and may be because of vomiting and gastro-esophageal regurgitation. The aim of the study was to assess whether regular treatment with metoclopramide, a D2-receptor antagonist with antiemetic and gastric prokinetic actions, could reduce the rate of pneumonia.