Acute Myocardial Infarction Clinical Trial
Official title:
Tako-Tsubo Cardiomyopathy and Cardiac Syndrome X: a Study on the Brain-heart Interactions in Two Orphan Cardiac Diseases.
The Tako-Tsubo Cardiomyopathy (TTC) and the Cardiac Syndrome X (CSX) are respectively acute
and chronic heart diseases, which mimic myocardial infarction and stable angina pectoris
without alterations of large coronary vessels. The causes and the most appropriate and best
treatment for these diseases have not been yet clarified, but there are indications, that
mental and psychosocial aspects may also contribute to these two diseases. So far, there is
no study, which has comprehensively evaluated the interactions between mind and heart in
these two conditions.
The purpose of this study is to search for possible differences in mental activity, response
to stressful events and function of specific areas of the brain deeply involved in relation
between mind and heart.
45 subjects will be recruited and divided equally into: patients with CSX, patients with TTC
(at least 6 months ago) and patients with previous acute myocardial infarction (at least 6
months ago). All participants will undergo a clinical interview and several questionnaires
that assess various mental functions, the stress response and the quality of life. In
addition, in a separate visit the participants will undergo a Magnetic Resonance Imaging
without contrast medium that helps to assess function of specific areas of the brain.
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