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Vomiting clinical trials

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NCT ID: NCT06080880 Recruiting - Clinical trials for Nausea With Vomiting Chemotherapy-Induced

Ondanstron Weekly vs Every 3 Weeks for Prevention of Nausea and Vomiting Induced by Chemotherapy Combined With PD-1 Blockade

Start date: December 1, 2023
Phase: N/A
Study type: Interventional

The aim of this randomized study is to compare the efficacy and safety of ondanstron weekly with every 3 weeks for the prevention of nausea and vomiting induced by chemotherapy combined with PD-1 blockade.

NCT ID: NCT06065722 Recruiting - Clinical trials for Chemotherapy Induced Nausea and Vomiting

Prevention of Breakthrough CINV in Patients Receiving Moderately or Highly Emetogenic Chemotherapy

Start date: September 9, 2023
Phase: Phase 2
Study type: Interventional

The purpose of the proposed study is to provide a clinical approach to chemotherapy induced nausea and vomiting (CINV) prophylaxis in cycle 2 of moderately emetogenic chemotherapy or highly emetogenic chemotherapy for patients who developed breakthrough CINV after cycle 1 based on the available data in the literature as well as the recommendations provided by established guidelines

NCT ID: NCT06031025 Recruiting - Diarrhea Clinical Trials

Prevalence and Natural History of Functional Gastrointestinal Disorders Among At-risk Infants.

FUSID
Start date: May 20, 2022
Phase:
Study type: Observational

The goal of this observational study is to learn about the prevalence and characteristics of functional gastrointestinal disorders (FGID) in at risk infants (former preterm infants and those with birth asphyxia) during the first 2 years of life. The main questions it aims to answer are: - evaluate the prevalence of symptoms related to gastro-esophageal reflux (GER), of functional gastrointestinal disorders during the first 2 years of life - describe growth parameters during follow-up up to the corrected age of 2 years Participants will be assessed clinically and with a structured questionnaire based on the Rome IV criteria to describe FGID.

NCT ID: NCT06029790 Recruiting - Postsurgical Ileus Clinical Trials

The Effect of Chewing Gum on Nausea, Vomiting and Bowel Function After Colorectal Surgery

Start date: January 10, 2024
Phase: N/A
Study type: Interventional

False feeding refers to promoting gastrointestinal peristalsis by seeing, smelling, chewing, and tasting food, not getting food into the gastrointestinal tract. Postoperative sham feeding uses gum to promote the healing of gastrointestinal peristalsis. Although not fully understood, the physiological theory underlying gum chewing (fake feeding) to stimulate peristalsis and reduce postoperative intestinal recovery time is that the oral and chewing stimulation provided by chewing gum stimulates a neurohumoral reflex that increases gastrointestinal fluid secretion. This increases gastrointestinal motility. In addition, oral stimulation and chewing can stimulate the vagus nerve, which is also involved in promoting peristalsis. Finally, none of the existing theories adequately explain the effect of chewing/gum chewing on reducing postoperative inflammation in the gut, which may result in a reduced incidence of postoperative infection. In previous studies, physiological changes associated with gum appear to promote normal gastrointestinal function and subsequent postoperative/anesthetic recovery. Although many studies have been conducted to examine the effectiveness of chewing gum in patients undergoing colorectal resection, the results have been inconsistent. This can be attributed to differences in intestinal injuries affecting bowel function, differences in time under anesthesia and differences in anesthetics or pain control agents used for pain control affecting bowel function, and recovery time of peristalsis. Given the many factors known to affect postoperative ileus, chewing gum as an intervention remains a safe, accessible, and inexpensive option that remains to be explored.

NCT ID: NCT06022705 Recruiting - Clinical trials for Nausea, Postoperative

Evaluation of the Effect of APFEL Risk Score and Fasting Periods on Postoperative Nausea and/or Vomiting

Start date: August 28, 2023
Phase:
Study type: Observational [Patient Registry]

This study, it is aimed to determine the effect of Apfel risk score and fasting times on postoperative nausea and vomiting (PONV).

NCT ID: NCT06017284 Recruiting - Clinical trials for Chemotherapy-induced Nausea and Vomiting

Thalidomide to Chemotherapy Related Nausea and Vomiting in Pancreatic Cancer

PTCA199-5
Start date: November 1, 2023
Phase: Phase 3
Study type: Interventional

The purpose of this study is to evaluate the efficacy of thalidomide on improving the quality of life for metastatic pancreatic cancer patients receiving gemcitabine and nab-paclitaxel chemotherapy.

NCT ID: NCT06017167 Recruiting - Clinical trials for Postoperative Nausea and Vomiting

Prophylaxis Against Postoperative Nausea and Vomiting After Laparoscopic Cholecystectomy

Start date: September 15, 2022
Phase: Phase 2
Study type: Interventional

The aim of the study is to compare antiemetic effects between dexmedetomidine and ondansteron in the first group versus dexamethasone and ondansteron in the second group. The primary outcome in this study is incidence of postoperative nausea and vomiting after laparoscopic cholecystectomy. The secondary outcomes are: - The severity of post operative nausea and vomiting. - Use of rescue antiemetic drugs. - Postoperative pain and sedation.

NCT ID: NCT05996887 Recruiting - Clinical trials for Nausea and Vomiting, Postoperative

Impact of ERAS on Postoperative Nausea and Vomiting After Sleeve

Start date: July 30, 2023
Phase: N/A
Study type: Interventional

The use of bariatric surgery in the treatment of severe obesity has several benefits in terms of sustainable weight loss, improvements, or resolution of several metabolic comorbidities as well as improved life expectancy. Gastric surgery, history of acid reflux and reduction in gastric size, in particular after laparoscopic sleeve gastrectomy (LSG), surgery may further contribute to postoperative nausea and vomiting (PONV). The combination of antiemetic drugs that act at different receptors is more effective than using only one drug in preventing PONV in patients with increased risk for these events.

NCT ID: NCT05988671 Recruiting - Clinical trials for Postoperative Nausea and Vomiting

Intraperitoneal Dexamethasone, Dexmedetomidine, and Dexamethasone-Dexmedetomidine Combination on Postoperative Nausea and Vomiting After Laparoscopic Cholecystectomy

Start date: August 10, 2023
Phase: Phase 3
Study type: Interventional

Nausea and vomiting are some of the most common complaints of patients after any anesthesia, which is often associated with postop-erative pain. The double-blind clinical trial study aimed to compare the prophylactic effect of dexamethasone and dexmedetomidine and their combination in reducing postoperative nausea and vomiting in patients undergoing laparoscopic cholecystectomy.

NCT ID: NCT05975385 Recruiting - Pain, Postoperative Clinical Trials

Acupuncture for Prevention of Postoperative Nausea and Vomiting After Laparoscopic Cholecystectomy

Start date: October 9, 2023
Phase: N/A
Study type: Interventional

The purpose is to find out if intraoperative acupuncture performed by needling PC 6 and LI4 point bilaterally, and Yin Tang point will help reduce the incidence postoperative nausea and vomiting in patients undergoing laparoscopic cholecystectomy when added to a prophylactic regimen consisting of ondansetron and dexamethasone. The hypothesis is that the addition of this acupuncture treatment to ondansetron and dexamethasone given for prophylaxis will help reduce the incidence of postoperative nausea and vomiting in patients undergoing laparoscopic cholecystectomy when compared to patients receiving ondansetron and dexamethasone without acupuncture.