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Sex Disparities in Hypoxic Vasodilation and Impact of Obesity

Healthy Clinical Trial

Official title:
Sex Disparities in Hypoxic Vasodilation and Impact of Obesity

Clinical Trial Summary

The purpose of this project is to examine key mechanisms contributing to sex-differences in hypoxic vasodilation and the impact of obesity, with particular emphasis on the sympathetic nervous system.

Clinical Trial Description

Patients with sleep apnea are at increased risk of developing cardiovascular disease - with women at potentially greater risk than men. Contributing mechanisms are not well understood, but may be related to how women respond to low oxygen and, given over 70% of patients with sleep apnea are obese, the impact of obesity. This project seeks to increase our understanding of mechanisms that may contribute to sex differences in the cardiovascular response to low oxygen with the hope that this knowledge will improve the efficacy of current therapies and support the discovery of novel therapeutics. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05219799
Study type Interventional
Source University of Missouri-Columbia
Contact Jacqueline K Limberg, Ph.D.
Phone 5738822544
Email limbergj@missouri.edu
Status Recruiting
Phase Early Phase 1
Start date March 14, 2023
Completion date July 2025
View Details
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