Atherosclerosis Clinical Trial
Official title:
The Role of Inflammation in Vascular Disease (Inflammationens Roll i kärlsjukdom)
Increasing evidence suggests that systemic low-grade inflammation may be a driving force of cardiometabolic complications, such as vascular dysfunction, atherosclerosis and ischemic heart disease. Thus, we will investigate the role of inflammation in cardiovascular disease.
Vascular reconstruction surgeries usually require a small piece of the vessel wall to be
excised. The excised vessel is generally discarded as medical waste: however, for patients
participating in the study, the excised tissue will be placed in saline and collected for
research use.
Tissue collected from individuals undergoing vascular surgery associated with peripheral
arterial diseases, aneurysm and/or other manifestations of atherosclerosis, vascular tissue
will be cultured ex vivo in the presence or absence of therapeutic agents, to determine if
these attenuate the inflammation associated with the atherosclerotic phenotype. Furthermore,
the protocol will also be carried out using vascular tissue from control patients, which have
undergone vascular surgery that is not associated with vascular disease (e.g. knee
replacement surgery, trauma, etc).
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