Male Infertility Clinical Trial
Official title:
Increased Testicular Cd2+ & Infertility With Varicocele ( a Varicose Vein in the Scrotum)
Varicose veins in the scrotum (varicocele) are responsible for >20% of male infertility in
the US. Varicocele are associated with decreased sperm number and markedly reduced sperm
fertilizing ability. Surgical repair or removal of varicocele restores fertility in only 1/3
of cases. The goal of this study is to identify markers that predict the outcome of
variocele correction. This would offer considerable health cost savings.
Based on preliminary findings, we will obtain testis biopsies and semen specimens from
infertile men with varicocele and prospectively examining the levels of cadmium, a toxic
metal, and expression of genes required for normal sperm function. The semen and biopsies
will be obtained during clinically dictated procedures. Cadmium and gene expression will be
compared with response to varicocele repair (i.e., increased sperm production; pregnancy).
n/a
Observational Model: Defined Population, Primary Purpose: Screening, Time Perspective: Longitudinal
Status | Clinical Trial | Phase | |
---|---|---|---|
Recruiting |
NCT05503862 -
Home Semen Testing in Men Beginning Attempts to Conceive
|
N/A | |
Recruiting |
NCT03307655 -
Relationship Between Nitric Oxide (NO) in Follicular Fluid and Sperm Fertilization Ability
|
N/A | |
Withdrawn |
NCT02839447 -
A Clinical Evaluation of Semen Quality Using the MiOXSYS™ System 2.0
|
||
Completed |
NCT00975117 -
Spermotrend in the Treatment of Male Infertility
|
Phase 3 | |
Completed |
NCT00756561 -
HOP-2A - Intratesticular Hormone Levels
|
N/A | |
Recruiting |
NCT04541459 -
Validation of New Devices Against Ambient Electromagnetic Radiation
|
Early Phase 1 | |
Completed |
NCT02889341 -
Valuation of Variable Dose of Docosahexanoic Acid for the Improvement of the Parameters of Male Fertility
|
N/A | |
Not yet recruiting |
NCT03167008 -
Vitamin D Level vs Semen Parameters
|
||
Completed |
NCT02268123 -
Correlating In Vitro Fertilization Outcomes After Euploid Blastocyst Transfer With Sperm DNA Fragmentation
|
||
Completed |
NCT01232465 -
Impact of Sperm DNA Integrity on In Vitro Cycles
|
N/A | |
Recruiting |
NCT00119925 -
'SPRING'-Study: "Subfertility Guidelines: Patient Related Implementation in the Netherlands Among Gynaecologists"
|
N/A | |
Completed |
NCT03552081 -
Tobacco and Sperm Genome: Effects of Smoking Cessation
|
N/A | |
Recruiting |
NCT05200663 -
Efficacy Comparison of Tamoxifen and Tamoxifen With Antioxidants on Semen Quality of Male With Idiopathic Infertility
|
Phase 2 | |
Completed |
NCT02025270 -
MSCs For Treatment of Azoospermic Patients
|
Phase 1/Phase 2 | |
Recruiting |
NCT06147700 -
Identifying Molecular Determinants of Infertility in Men (MODIFY)
|
||
Recruiting |
NCT06188936 -
Home Semen Analysis Tests as a Screening Tool for Fertility Patients
|
N/A | |
Recruiting |
NCT04200118 -
Epigenetic and Genetic Effects in Cancer Patients: Analysis Pre and After Treatment
|
||
Terminated |
NCT02605070 -
Pilot Study on the Effects of FSH Treatment on the Epigenetic Characteristics of Spermatozoa in Infertile Patients With Severe Oligozoospermia
|
Phase 3 | |
Completed |
NCT01407432 -
Impact of Folates in the Care of the Male Infertility
|
Phase 3 | |
Completed |
NCT00596739 -
A Study of the Pre- and Post-operative Semen Analyses and Reproductive Hormone Levels of Men Undergoing Weight-reduction Surgery
|
N/A |