Identifying Molecular Determinants of Infertility in Men (MODIFY)

Status Recruiting

Clinical Trial Summary

The purpose of this study is to understand the underlying mechanisms of infertility caused by unknown factors. The investigator propose to identify small non-coding RNA (sncRNA) biomarkers of infertility and advance towards developing a more accurate and robust approach for infertility diagnosis.

Clinical Trial Description

The goal of the study is to identify small non-coding RNA signatures of infertility in men through the comparison of sperm sncRNA profiles from around 100 men (21-50 years of age). The participants will be classified into fertile and infertile groups by the conventional method. Through the project, the investigator intends to understand the underlying mechanisms of idiopathic infertility. By utilizing semen as liquid biopsy, through sperm sncRNA profiling and comparison (infertile vs fertile). The investigator proposes to identify the sncRNA (miRNAs, piRNAs and tRFs) as biomarkers of infertility. The investigator proposes to generate a validated signature of sncRNAs that will help in selecting high quality sperms for IVF. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT06147700
Study type	Observational
Source	Singapore Institute for Clinical Sciences
Contact	Candida Vaz
Phone	8854 6302
Email	candida_vaz@sics.a-star.edu.sg
Status	Recruiting
Phase
Start date	October 11, 2023
Completion date	June 30, 2024

View Details

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