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Uveomeningoencephalitic Syndrome clinical trials

View clinical trials related to Uveomeningoencephalitic Syndrome.

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NCT ID: NCT05627739 Recruiting - Clinical trials for Mycophenolate Mofetil

A Study of Mycophenolate Mofetil Combined With Glucocorticoid Therapy in Relapse Vogt-Koyanagi-Harada Disease

Start date: October 1, 2021
Phase:
Study type: Observational

This project is designed to test the hypothesis that Mycophenolate Mofetil is clinically useful for patients with relapse Vogt-Koyanagi-Harada disease

NCT ID: NCT05590416 Recruiting - Adalimumab Clinical Trials

A Study of Adalimumab in Acute Vogt-Koyanagi-Harada Disease

Start date: June 1, 2021
Phase:
Study type: Observational

This project is designed to test the hypothesis that adalimumab is clinically useful for patients with acuta Vogt-Koyanagi-Harada disease

NCT ID: NCT05496530 Recruiting - Clinical trials for Diabetic Macular Edema

Custom Needle Preparation for Suprachoroidal Steroid Injection (One Year Results)

Start date: July 10, 2022
Phase: N/A
Study type: Interventional

Suprachoroidal drug delivery is a recent route for managing various ocular conditions. Safety and long term results are still under investigations.

NCT ID: NCT05349747 Not yet recruiting - Uveitis Clinical Trials

Outcome of Treatment of Uveitis With Biologic Drugs in Resistant Cases Vogt-koyanagi-Harada Disease

Start date: April 30, 2022
Phase:
Study type: Observational

- Reviewing the characteristics of patients with uveitis caused by Vogt-Koyanagi-Harada Syndrome treated at Assiut University Hospital at the Department of Ophthalmology and Department of Rheumatology, Physical Medicine, and Rehabilitation including the ocular features in terms of uveitis location, type and complications and systemic features of those subjects who showed an inadequate response to conventional immunomodulatory drugs. - Assess the results of treatment with biologic drugs, including rates of failure and adverse events. This will help uveitis specialists to reach a conclusion about the best treatment protocols for Uveitis in Vogt-Koyanagi-Harada Syndrome in our population in terms of safety, efficacy, and cost-effectiveness.

NCT ID: NCT05120687 Recruiting - Clinical trials for Vogt Koyanagi Harada Disease (VKH)

Corticosteroid Combining Noncorticosteroid Systemic Immunomodulatory Therapy in VKH

Start date: October 15, 2021
Phase:
Study type: Observational

The aim of this study is to evaluate the efficacy and safety of corticosteroidcombining noncorticosteroid systemic immunomodulatory therapy (NCSIT) for the treatment of Vogt Koyanagi Harada disease (VKH).

NCT ID: NCT05031143 Completed - Clinical trials for Vogt Koyanagi Harada Disease

Suprachoroidal Triamcinolone Acetonide in Harada's Retinal Detachment

Start date: April 1, 2020
Phase: Phase 2/Phase 3
Study type: Interventional

Suprachoroidal injection, a novel technique for delivering ocular therapies, may facilitate targeted therapeutic delivery to the choroidal and retinal structures than intravitreal injection

NCT ID: NCT04126850 Not yet recruiting - Behçet Disease Clinical Trials

Pilot Project: The Amplicon and Metatranscriptomic Study of Intra and Extra Intestinal Microbiome in Non-infectious Uveitis Disease

Start date: November 1, 2019
Phase:
Study type: Observational

This study aimed to discover the composition on the microbiome in several sites of the human body; and to find out the difference in microbiome composition on ocular fluid, blood, and feces before and after therapy in uveitis patient with history of autoimmune disease (Behcet and Vogt-Koyanagi-Harada) and idiopathic uveitis

NCT ID: NCT04101604 Recruiting - Clinical trials for Diabetic Retinopathy

Biomarkers of Common Eye Diseases

Start date: September 26, 2019
Phase:
Study type: Observational

To identify biomarkers of common eye diseases based on single-cell sequencing technologies using PBMC samples. These diseases include uveitis, diabetic retinopathy, age-related macular degeneration and polypoid choroidal vasculopathy. Our study may provide new insight into the underlying mechanisms, and reveal novel predictors and intervention targets for the diagnosis, prognosis and treatment of these diseases.

NCT ID: NCT04025476 Recruiting - VKH Syndrome Clinical Trials

Immune Profile of Acute VKH Patients PBMC

IPV
Start date: July 20, 2019
Phase:
Study type: Observational

The investigators will collect blood samples of different courses of VKH patients for investigating immune profile, observe major immune cells number ,functional and membrane molecular changes in the course of treatment, to investigate pathogenesis of VKH. Meanwhile, the investigators will collect clinical data of VKH patients to observe choroid and retina change in different courses.

NCT ID: NCT03811366 Completed - Inflammation Clinical Trials

Multimodal Analysis and Electroretinogram in VKH From Acute Onset - Part I

Start date: June 1, 2011
Phase: N/A
Study type: Interventional

Patients with acute onset Vogt-Koyanagi-Harada disease (VKHD) was prospectively included in this study. They were systematically followed with clinical, posterior segment imaging exams and full-field electroretinogram during a minimum 24-month of follow-up. All patients were treated with 3-day methylprednisolone pulse therapy followed by 1mg/day oral prednisone with a slow tapper during a median of 13 months. Non-steroidal immunosuppressive therapy (IMT) was introduced in cases of refractory disease or in cases of prednisone intolerance. Outcome measured by full-field electroretinogram was analyzed and patient was grouped as electroretinogram stable or electroretinogram worsening. Clinical data was analyzed in these two electroretinogram-based groups.