Multiple Sclerosis Clinical Trial
Official title:
A Monocentric, Randomized, Controlled Trial to Test the Efficacy of Interferon-beta in the Treatment of Disseminated Encephalomyelitis (ED)-Associated and Primary Intermediate Uveitis in Comparison to Standard Treatment (TEAM)
The purpose of this study is to investigate if interferon beta is superior to the standard treatment with Methotrexate for the treatment of intermediate uveitis and macular edema.
Deuter et al were the first to show the anti-edematous effect of interferon alpha on
inflammatory macular edema (Deuter C. M. E., Kötter I., Günaydin I., Zierhut M. Treatment of
the Cystoid Macular Oedema in Behçet's Disease with Interferon Alfa-2a, Retina, in press).
In an interventional, multi-centric pilot-study we could demonstrate a positive effect of
interferon beta on ED associated uveitis, especially in reducing the macular edema.
Undesired effects of the treatment were not observed.
Thus we want to test the efficacy and safety of interferon beta compared to standard
treatment with methotrexate in a prospective, clinically controlled trial on patients who
suffer from intermediate uveitis with inflammatory macular edema who either have associated
ED or have no systemic disease association, i.e. primary uveitis. .
;
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Crossover Assignment, Masking: Single Blind (Outcomes Assessor), Primary Purpose: Treatment
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