Multiple Sclerosis Clinical Trial
Official title:
Feasibility and Reliability of Multimodal Evoked Potentials
Multimodal Evoked potentials (mmEP) reflect disease course of multiple sclerosis (MS) and are
potentially suited as a biomarker for disease progression.
The acquisition of evoked potentials (EP) in this observatory trial is to evaluate the
feasibility and test-retest reliability of motor and somato-sensory EP (MEP and SSEP) in an
international multicenter setting in healthy subjects and subjects with multiple sclerosis
(MS).
Multimodal EP (mmEP) is being developed as a predictive biomarker to determine the clinical response to therapy. MEP and SSEP contributes significantly to the predictive value of mmEP. The variability of MEP and SSEP has limited its use in multicenter clinical trials. Recent technological advances and standardization of procedures has decreased the variability. The objective of this study is to evaluate the reliability of MEP and SSEP and feasibility of performing MEP and SSEP in an international, multicenter setting. Establishment of the reliability and feasibility of MEP and SSEP will allow for further development of this predictive biomarker in future clinical trials. ;
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