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Uterine Hemorrhage clinical trials

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NCT ID: NCT02248194 Completed - Clinical trials for Dysfunction Uterine Bleeding

Tactile Electrosurgical Ablation in Cases of Dysfunctional Uterine Bleeding

TEA
Start date: April 2010
Phase: Phase 2
Study type: Interventional

Abnormal uterine bleeding (AUB) is any alteration in the pattern or volume of menstrual blood flow and heavy menstrual bleeding affects up to 30% of women at some time during their reproductive years. Abnormal menstruation can be due to conditions such as pregnancy complication uterine fibroids and adenomyosis, but in a large proportion of cases, the etiology is unclear, a condition generally referred to as dysfunctional uterine bleeding (DUB). Treatment options for DUB include symptomatic medical treatment or surgery, traditionally hysterectomy. Hysteroscopically guided endometrial ablation methods have been shown to be effective and safe alternatives to hysterectomy for management of DUB. These methods require particular skills and experience and a long learning curve to be performed effectively and safely. Through the past three decades DUB patients in Assiut university hospital were treated with either electrosurgical ablation or hysterectomy. When faced with hysteroscopic challenges during transcervical resection of the endometrium or rollerball coagulation, we used to shift to thermal balloon as backup method . However, expensive uterine balloon could not infrequently be afforded because of financial constrains and limited health resources . Therefore, another method was used as backup for hysteroscopic failures. It was first tried via insulating the conventional double-ended uterine curette then through a specially designed tactile electrosurgical ablation (TEA) probe.The technique of TEA is largely similar to the dilatation and curettage procedure both principally and practically. Hence, the basic requirements for its performance are the general awareness with electrosurgical principles and adequate experience in performing dilatation and curettage. TEA is done by specially designed tactile diathermy probe that carried the job of electrosurgical ablation without hysteroscopy or distension media first in an experimental session that clearly clarified the reproducibility of the depth of thermal damage and safety of the tactile electrosurgical ablator . Thereafter, TEA was successfully performed with satisfactory short and medium term outcomes for ten cases with DUB during an active, relentless bleeding attack. TEA is done under laparoscopic monitoring. The aim of the present work is to present TEA as a simple, inexpensive, novel backup approach for treatment of DUB.

NCT ID: NCT02192606 Completed - Pelvic Pain Clinical Trials

Does 3D Laparoscopy Improve Vaginal Cuff Suture Time?

3DRCT
Start date: November 2013
Phase: N/A
Study type: Interventional

The objective aim is to evaluate whether the use of 3D laparoscopy facilitates the vaginal cuff closure of the vaginal cuff during a total laparoscopic hysterectomy among novice laparoscopists (PGY 2-4, Fellow). This is a randomized single blinded controlled trial comparing the difference in 2D vs. 3D in regards to vaginal cuff closure time stratified by residents and fellows. Patients will undergo a total laparoscopic hysterectomy and will be randomized to either 2D versus 3D.

NCT ID: NCT02147197 Completed - Leiomyoma Clinical Trials

A Study of the Efficacy and Safety of a 3-month Treatment Course of Ulipristal Acetate for the Treatment of Abnormal Uterine Bleeding Associated With Leiomyomas

Start date: March 31, 2014
Phase: Phase 3
Study type: Interventional

This study will evaluate the superiority of ulipristal acetate versus placebo for the treatment of abnormal uterine bleeding associated with uterine fibroids

NCT ID: NCT02147158 Completed - Leiomyoma Clinical Trials

A Study of the Efficacy and Safety of Ulipristal Acetate Intermittent Treatment for Abnormal Uterine Bleeding Associated With Leiomyomas

Start date: January 29, 2014
Phase: Phase 3
Study type: Interventional

This study will evaluate the superiority of ulipristal acetate versus placebo for the treatment of abnormal uterine bleeding associated with uterine fibroids

NCT ID: NCT02059954 Completed - Uterine Fibroids Clinical Trials

Vaginal vs. Laparoscopic Hysterectomy

Start date: January 2014
Phase: N/A
Study type: Interventional

Hysterectomy for benign indication is one of the most common surgical procedures in women. Numerous reviews and guidelines recommend the vaginal approach for benign hysterectomy, but the proportion of laparoscopic (and robotic) hysterectomies is increasing. This study will compare a range of clinical and subjective outcomes of vaginal vs. total laparoscopic hysterectomy. Outcomes include operating time, postoperative recovery, return to work as well as cosmesis, quality of life and sexual health.

NCT ID: NCT02029144 Completed - Clinical trials for Abnormal Uterine Bleeding

Observational Study of Dydrogesterone in Cycle Regularization

Start date: December 2013
Phase: N/A
Study type: Observational

Dydrogesterone has been widely used worldwide for various gynecological and obstetric indications: - Dydrogesterone is effective in cycle regulation treatment. - Dydrogesterone is recognized as none interference to hypothalamus pituitary ovary (HPO) axis in the recommended dosage. - Dydrogesterone might have non-negative effect on glucose and lipid metabolic.

NCT ID: NCT01992718 Completed - Uterine Fibroids Clinical Trials

What Are we Missing? Diagnosing Uterine Adenomyosis Using Ultrasound Elastography

Start date: November 2013
Phase: Early Phase 1
Study type: Interventional

To improve the clinical care of women with pelvic pain and abnormal uterine bleeding due to benign uterine conditions including leiomyomas (uterine fibroids) and adenomyosis by evaluating the accuracy of radiology diagnostic exams (MRI(magnetic resonance imaging), ultrasound and ultrasound with elastography).

NCT ID: NCT01968135 Completed - Contraception Clinical Trials

Does Concomitant Use of Combined Oral Hormonal Steroids Stop Bleeding in Women Using Etonogestrel Implants (Implanon/Nexplanon®)?: A Randomized Controlled Study

Start date: October 2013
Phase: Phase 2
Study type: Interventional

The investigators' specific aims are to determine if more women using ENG contraceptive implants who report a bleeding-spotting episode of at least seven days will stop bleeding within 3 days of beginning a 14-day course of combined oral hormonal steroids, as compared to women receiving 14 days of placebo.

NCT ID: NCT01916343 Completed - Clinical trials for Hysterectomy for Abnormal Uterine Bleeding

Laparoscopic Gynecology Curriculum for Residents

Start date: July 2013
Phase: N/A
Study type: Interventional

Gynecologists are currently using laparoscopy to perform many surgeries traditionally approached by laparotomy. The technical skills required for laparoscopic surgery are different than the skills required for laparotomy, causing a prolonged learning curve. Currently there is no standardized laparoscopy curriculum for gynecology residents. This study aims to develop a specific evidence-based surgical skills gynecologic curriculum that could be instituted in residency programs at a national and international level. The investigators will then validate the curriculum using Obstetrics and Gynecology residents through a cognitive examination, a technical skills examination, and a video recording of performance in the operating room. HYPOTHESIS: The investigators aim is to design a standardized evidence-based comprehensive laparoscopic curriculum that focuses on cognitive knowledge, surgical skills, and team training exercises. The investigators hypothesize that residents in the experimental curriculum-trained group will perform better than the residents in the traditional residency curriculum-trained group on a cognitive examination, a technical skills examination, and in the operating room. The operating room performance will be judged by blinded experts on a previously validated evaluation tool.

NCT ID: NCT01908738 Completed - Clinical trials for Abnormal Uterine Bleeding

Effectiveness of Paracervical Block Versus Lidocaine Spray During Endometrial Biopsy

Start date: September 2013
Phase: N/A
Study type: Interventional

The purpose of this study to determine effectiveness of paracervical block, lidocaine spray and only oral analgesic drugs for pain relief during endometrial biopsy.