Type 2 Diabetes Post Exercise Arterial Stiffness

Status Not yet recruiting

Clinical Trial Summary

The overall aim of this research proposal is to determine the impact of GLP1 agonists on post-exercise arterial stiffness. Therefore, the investigators will examine the cardiovascular responses to exercise in individuals with Type 2 Diabetes mellitus (T2DM) taking these medications during and following a graded maximal exercise test.

Clinical Trial Description

Type 2 diabetes mellitus (T2DM) is a significant public health concern associated with increased cardiovascular morbidity and mortality. Notably, individuals with T2DM often exhibit increased arterial stiffness, a key indicator of cardiovascular risk. Pharmacological interventions such as GLP1 agonists have emerged as crucial treatments for T2DM, offering glycemic control and potential cardiovascular benefits, including improvements in blood pressure and arterial stiffness. However, while the effects of GLP1 agonists on glycemic control and blood pressure regulation have been explored, their impact on arterial stiffness, specifically in response to exercise, remains largely unexplored in individuals with T2DM. Arterial stiffness is a critical marker of cardiovascular health, and its reduction is associated with decreased cardiovascular risk which include lowered blood pressure. Therefore, the overall aim of this research is to investigate whether GLP1 agonists attenuate arterial stiffness post exercise and reduce peak exercise blood pressure in individuals with T2DM. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT06438874
Study type	Interventional
Source	University of Illinois at Chicago
Contact	Ronald E Jackson, PhD
Phone	708-536-0594
Email	rjacks40@uic.edu
Status	Not yet recruiting
Phase	N/A
Start date	July 2024
Completion date	December 2024

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