Type 2 Diabetes Clinical Trial
Official title:
Multidimensional Accurate Diagnosis and Treatment Technology and Clinical Transformation of Type 2 Diabetes Nephropathy
Diabetes nephropathy (DN) is one of the most serious microvascular complications of diabetes, and also an important cause of death and disability of diabetes patients. There is no specific clinical staging of type 2 diabetes nephropathy at home and abroad, and there is no comprehensive study to comprehensively describe the occurrence and development of type 2 diabetes nephropathy through sensitive biomarkers, microvascular disease imaging and functional detection, digital markers and other multi-dimensional diagnosis and evaluation methods. Therefore, our research aims to establish a long-term follow-up queue for the whole cycle of diabetes nephropathy, develop multi-dimensional diagnostic and progress digital markers for diabetes nephropathy, develop a multimodal non-invasive diagnostic model and a new clinical staging/typing, and create a multi-dimensional accurate diagnosis and treatment system for type 2 diabetes nephropathy combining traditional Chinese and western medicine.
| Status | Recruiting |
| Enrollment | 2000 |
| Est. completion date | December 31, 2026 |
| Est. primary completion date | November 1, 2026 |
| Accepts healthy volunteers | |
| Gender | All |
| Age group | 18 Years and older |
| Eligibility | Inclusion Criteria: Age = 18 years old, regardless of gender; Type 2 diabetes; Having a complete medical history and clinical data; If the patients with type 2 diabetes combined with CKD underwent renal biopsy, the pathological diagnosis should be clear; Patients voluntarily signs an informed consent form. Exclusion criteria: Incomplete medical history or clinical data; Patients with hereditary kidney disease; Combined urinary tract infection; Merge autoimmune system diseases; Patients with malignant tumor were expected to survive less than 6 months; Pregnancy and lactation. |
| Country | Name | City | State |
|---|---|---|---|
| China | Chinese PLA General Hospital | Beijing |
| Lead Sponsor | Collaborator |
|---|---|
| Chinese PLA General Hospital | Beijing Friendship Hospital, Beijing Hospital, Beijing Municipal Science & Technology Commission, Beijing Tongren Hospital, China-Japan Friendship Hospital, Dongzhimen Hospital, Beijing, Xuanwu Hospital, Beijing |
China,
| Type | Measure | Description | Time frame | Safety issue |
|---|---|---|---|---|
| Primary | change in estimated glomerular filtration rate (eGFR) from baseline | eGFR is calculated using the CKD-EPI formula, involving gender, age, and serum creatinine. | 24months |
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