Type 2 Diabetes Clinical Trial
Official title:
A Randomized, Prospective, Parallel Design Study to Compare the Effectiveness of Sitagliptin Versus Glimepiride on Endothelial Dysfunction During an Oral Glucose Loading in Drug Naive Patients With Type 2 Diabetes.
To investigate whether single administration of sitaglitpin can restore acute endothelial
dysfunction and ameliorate impaired increase of the number of endothelial progenitor cells
(EPCs) after oral glucose loading in patients with T2DM.
To compare the effect of sitagliptin and glimepiride on endothelial function evaluated by
flow-mediated vasodilatation (FMD) and the number of circulating EPCs in patients with T2DM.
Acute and chronic improvement of endothelial function is expected through the pleiotropic
effect of DPP-4 inhibitors. A randomized, prospective, open-labeled, parallel design. The
duration of treatments with sitagliptin or glimepiride is 12 weeks. The number of study
centers is a single (Dokkyo Medical University Hospital). Participants will be randomized
into the two treatment groups; (a) 50mg sitagliptin (N=15) and (b) 1mg glimepiride (N=15).
Anti-Hyperglycemic effect is expected to be similar according to our study
;
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
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