Effects of Sedentary Behaviour on Metabolic Parameters

Type 2 Diabetes Clinical Trial

Official title:

Effects of Sedentary Behaviour on Metabolic Parameters

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02088827
• Other study ID #: H13-01886
• Status: Completed
• Phase: N/A
• Start date: January 1, 2015
• Est. completion date: September 1, 2021

Study information

• Verified date: October 2022
• Source: University of British Columbia
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The rates of sedentary activity are increasing. Studies have shown that time spent on doing sedentary activities is an independent risk factor for cardiovascular disease. Prior studies have shown that interrupting inactivity improved the body's handling of blood glucose and gene expression. The investigators plan to explore this further by examining the effects of interrupting 4 hours of inactivity with 2 minutes of moderate intensity exercise every 20 minutes on the following metabolic parameters: blood pressure, cortisol, C-Reactive Protein, glucose and insulin levels.

Description:

There is a current trend towards increasing time spent in sedentary behaviour. More jobs are being automated, and more time is spent in front of a computer, playing video games and watching television.Current studies suggest that sedentary behaviour is an independent risk factor for cardiovascular disease. Increasing time spent in sedentary behaviour has been linked to all-cause mortality, markers of cardiovascular disease and metabolic syndrome. However, the data is mainly from cross-sectional studies and based on self-recall, limiting the ability to draw definitive conclusions.

Current exercise guidelines recommend at least 150 minutes of moderate to vigorous intensity exercise per week. It may be difficult for some elderly people to meet these guidelines. Older adults with diabetes are already at a higher risk fo conditions that are affected by sedentary behaviour and may stand to benefit the most from intervention.

This study proposes to study the effects of breaking up sedentary activity with moderate intensity exercise on multiple metabolic parameters in older adults with diabetes.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 12
• Est. completion date: September 1, 2021
• Est. primary completion date: May 12, 2020
• Accepts healthy volunteers: No
• Gender: All
• Age group: 65 Years and older

Eligibility

Inclusion Criteria:

• 65 years of age or older

• type 2 diabetes managed with diet or oral hypoglycemic agents

Exclusion Criteria:

• using insulin to manage diabetes

• baseline of pre-session blood glucose reading equal to or greater than 10 mmol/L

• any medical condition that would limit the ability to perform activity portion of the study

• people not comfortable exercising on a stationary bicycle

• subject answers yes to one of more of the questions in the Physical Activity Readiness Questionnaire

Related Conditions & MeSH terms

• Diabetes Mellitus, Type 2
• Sedentary Lifestyle
• Type 2 Diabetes

Intervention

Other:
• Inactivity
Subjects will remain inactive (lying on a bed) for 4 hours.
• Activity
Subjects will spend 4 hours of inactivity (lying on a bed) broken up by 2 minutes of moderate intensity biking (on a stationary bike) every 20 minutes.

Locations

Country	Name	City	State
Canada	Gerontology Research Lab	Vancouver	British Columbia

Sponsors (1)

Lead Sponsor	Collaborator
University of British Columbia

Country where clinical trial is conducted

Canada, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Blood Pressure		every 60 minutes for 4 hours
Secondary	C Reactive Protein		every 60 minutes for 4 hours
Secondary	Insulin Levels		every 60 minutes for 4 hours
Secondary	Blood glucose levels		every 60 minutes for 4 hours