Type 2 Diabetes Clinical Trial
Official title:
The Relation Between Plasma Irisin Level and Endothelial Dysfunction in Type 2 Diabetes
Irisin is a signaling protein that is released into the blood from skeletal muscle after
proteolysis of the membrane protein FNDC5 . FNDC5, encoded by the Fndc5 gene. Irisin
activity on subcutaneous white adipose tissue, both in culture and in vivo, stimulated UCP1
expression and induction of brown adipocytes in white adipose tissue depots, a process known
as white fat ''browning''. Irisin increases total energy expenditure in animal models, and
irisin expression in mice fed a high fat diet resulted in a significant improvement in
glucose tolerance and a reduction in fasting insulin levels. Collectively, these data
suggest that decreased serum irisin levels may be associated with the development of insulin
resistance and Type 2 diabetes. Indeed, some studies showed that irisin levels were
decreased in newly diagnosed Type 2 diabetes.
Endothelial dysfunction is an early physiological event in atherosclerosis. However, to
date, no data are available on the relationship between circulating irisin and endothelial
dysfunction in diabetes. Therefore, the investigators hypothesized that circulating irisin
level is associated with endothelial dysfunction.
n/a
Observational Model: Case Control, Time Perspective: Cross-Sectional
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