Type 2 Diabetes Clinical Trial
Official title:
The Effects of Acute Exercise on Glucose Kinetics, Beta-cell Function and the Incretin Effect in Subjects Representative of the Whole Glucose Tolerance Continuum
Human volunteers will be stratified by oral glucose tolerance status: normal glucose
tolerant, impaired glucose tolerant, and type 2 diabetic. All subjects will undergo 4
experimental trials: [1] an oral glucose tolerance test (OGTT) combined with infused and
ingested stable isotopes of glucose to assess glucose kinetics. [2] a 1 hour bout of cycling
exercise at 50% of maximum power output, immediately followed by the same OGTT combined with
stable isotope glucose tracers used in trial 1. [3] an isoglycemic clamp to match the plasma
glucose profile measured in trial 1. [4] a 1 hour bout of cycling exercise at 50% of maximum
power output, immediately followed by an isoglycemic clamp to match the plasma glucose
profile measured in trial 2.
Exercise-induced changes in oral glucose tolerance, glucose kinetics, insulin and glucagon
secretion, and the incretin effect will be examined. The exercise responses will be compared
between the subjects groups of different glucose tolerance status.
n/a
Allocation: Non-Randomized, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Basic Science
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