Type 2 Diabetes Clinical Trial
Official title:
Training, Detraining and Retraining Effects on Glycemic Control and Physical Fitness in Patients With Type 2 Diabetes
Verified date | April 2012 |
Source | Democritus University of Thrace |
Contact | n/a |
Is FDA regulated | No |
Health authority | Greece: Ministry of Health and Welfare |
Study type | Interventional |
- This study examine the effects of training, detraining and retraining, using a combined
strength and aerobic exercise program, on physiological parameters in patients with
type 2 diabetes.
- Thirteen women with type 2 diabetes followed a supervised aerobic and strength training
program for 9 months, interrupted for 3 months (detraining) and resumed again for a
period of 9 months (retraining).
- Training improved body mass index, fasting plasma glucose,postprandial glucose,
glycosylated hemoglobin, peak oxygen consumption,power output and total muscle
strength. Detraining reversed PPG, HbA1C and physical fitness parameters. Resumption of
training however, improved further the initial training adaptations.
- Diabetic patients should follow a regular and uninterrupted exercise program throughout
life in order to control glucose metabolism and improve health status.
Status | Completed |
Enrollment | 13 |
Est. completion date | June 2010 |
Est. primary completion date | September 2008 |
Accepts healthy volunteers | No |
Gender | Female |
Age group | 45 Years to 65 Years |
Eligibility |
Inclusion Criteria: - Type 2 diabetes - without micro- and macroangiopathy Exclusion Criteria: - type 1 diabetes - cardiovascular disease, - confirmed retinopathy/nephropathy/neuropathy, - uncontrolled diabetes mellitus (HbA1c>10%). |
Intervention Model: Single Group Assignment, Masking: Single Blind (Investigator), Primary Purpose: Treatment
Country | Name | City | State |
---|---|---|---|
Greece | Savvas P. Tokmakidis | Komotini |
Lead Sponsor | Collaborator |
---|---|
Democritus University of Thrace | Aristotle University Of Thessaloniki |
Greece,
American College of Sports Medicine; American Dietetic Association; Dietitians of Canada. Joint Position Statement: nutrition and athletic performance. American College of Sports Medicine, American Dietetic Association, and Dietitians of Canada. Med Sci Sports Exerc. 2000 Dec;32(12):2130-45. Erratum in: Med Sci Sports Exerc 2001 Jan;33(1):following table of contents. — View Citation
Castaneda C, Layne JE, Munoz-Orians L, Gordon PL, Walsmith J, Foldvari M, Roubenoff R, Tucker KL, Nelson ME. A randomized controlled trial of resistance exercise training to improve glycemic control in older adults with type 2 diabetes. Diabetes Care. 2002 Dec;25(12):2335-41. — View Citation
Dunstan DW, Daly RM, Owen N, Jolley D, De Courten M, Shaw J, Zimmet P. High-intensity resistance training improves glycemic control in older patients with type 2 diabetes. Diabetes Care. 2002 Oct;25(10):1729-36. — View Citation
Tokmakidis SP, Spassis AT, Volaklis KA. Training, detraining and retraining effects after a water-based exercise program in patients with coronary artery disease. Cardiology. 2008;111(4):257-64. doi: 10.1159/000127737. Epub 2008 Apr 23. — View Citation
Tokmakidis SP, Volaklis KA. Training and detraining effects of a combined-strength and aerobic exercise program on blood lipids in patients with coronary artery disease. J Cardiopulm Rehabil. 2003 May-Jun;23(3):193-200. — View Citation
Tokmakidis SP, Zois CE, Volaklis KA, Kotsa K, Touvra AM. The effects of a combined strength and aerobic exercise program on glucose control and insulin action in women with type 2 diabetes. Eur J Appl Physiol. 2004 Aug;92(4-5):437-42. — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Changes from baseline in glycemic control measurements (follow-up for 21 months) at training (9 months), detraining (3 months) and retraining (9 months) | Glycemic control was evaluated by the measurement of fasting plasma glucose (FPG), postprandial glucose (PPG) and glycosylated hemoglobin (HbA1C). PPG was calculated by the mean of four values measured at the first week of every period (baseline, 9th, 12th and 21st months). | Changes from baseline in HbA1C, FPG and PPG at training (9 months), detraining (11 months) and retraining (21 months) | No |
Secondary | Evaluation of body composition | Anthropometric Assessment: Body weight, height, BMI and waist circumference (WC). | Changes from baseline in body composition assessment at training (9 months), detraining (3 months), retraining (9 months) | No |
Secondary | Peak oxygen consumption (VO2peak) | Measurement of Peak Oxygen Uptake: Patients underwent a symptom-limited graded exercise test on a cycle-ergometer (60 rpm). The initial load was set at 25W and increased gradually by 25W every 2-min until the patients were unable to continue. VO2peak was determined by open-circuit spirometry (E. Jaeger, IEC 601-1, Germany). | Changes from baseline in VO2peak at training (9 months), detraining (11 months) and retraining (21 months) | No |
Secondary | Measurement of muscular strength in patients with type 2 diabetes | Muscle Strength: Maximum strength was measured with the one-repetition maximum (1 RM) method and total muscle strength was calculated as the sum of leg extension and bench press. | Changes from baseline in muscular strength at training (9 months), detraining (11 months) and retraining (21 months) | No |
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