Type 2 Diabetes Clinical Trial
Official title:
Training, Detraining and Retraining Effects on Glycemic Control and Physical Fitness in Patients With Type 2 Diabetes
- This study examine the effects of training, detraining and retraining, using a combined
strength and aerobic exercise program, on physiological parameters in patients with
type 2 diabetes.
- Thirteen women with type 2 diabetes followed a supervised aerobic and strength training
program for 9 months, interrupted for 3 months (detraining) and resumed again for a
period of 9 months (retraining).
- Training improved body mass index, fasting plasma glucose,postprandial glucose,
glycosylated hemoglobin, peak oxygen consumption,power output and total muscle
strength. Detraining reversed PPG, HbA1C and physical fitness parameters. Resumption of
training however, improved further the initial training adaptations.
- Diabetic patients should follow a regular and uninterrupted exercise program throughout
life in order to control glucose metabolism and improve health status.
During the last decades, the positive effects of aerobic exercise in patients with type 2
diabetes have been well documented. Recently, resistance exercise has gained popularity in
diabetic patients since several studies have indicated that this type of training is safe
and induces favorable adaptations in physical fitness and metabolic profile. According to
recent scientific evidence, a complete rehabilitation program for patients with type 2
diabetes should combine both strength and aerobic exercise; thus the American Diabetic
Association in their latest guidelines recommends strength training as part of an exercise
program at least two times a week.
On the contrary to the well documented effects of physical training, there is lack of data
on the negative alterations of detraining in patients with type 2 diabetes. The partial or
complete loss of training-induced adaptations as a consequence of training reduction or
cessation is well-documented by several detraining studies in healthy subjects, older
individuals and patients with coronary artery disease.
For example, the investigators know that even 6 days of physical inactivity reduces insulin
action in well-trained runners which is attributed to the significant reduction in the
muscle GLUT-4 level. Factors such as illness, injury, travel or vacation may interrupt the
training process for longer periods, affecting the treatment in people with type 2 diabetes.
For this population, it is important to quantify changes in physiological and metabolic
parameters resulting from the cessation of exercise, since exercise training is a major
therapeutic method.
To the best of our knowledge, there is no data concerning the loss of physiological
adaptations which occurs after exercise cessation in patients with type 2 diabetes, which
have previously trained for a long period of time. The current study evaluated the effects
of three months of detraining after nine months of a combined strength and aerobic training
program on glycemic control, body composition, peak oxygen consumption (VO2peak) and
muscular strength in patients with type 2 diabetes. Further, the investigators examined the
extent of the regained adaptations after the resumption of training for a period of nine
months.
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Intervention Model: Single Group Assignment, Masking: Single Blind (Investigator), Primary Purpose: Treatment
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