Type 2 Diabetes Clinical Trial
Official title:
Study of Comparison the Treatment Effect Between Gastric Bypass and Exenatide in Type 2 Diabetes
Objectives: To investigate the treatment effect between Gastric Bypass and Exenatide in Type 2 Diabetes in our hospital, in order to investigate the possible mechanism of Gastric Bypass and Exenatide.
Methods:
60 Type 2 diabetes in our hospital will divide into 3 groups: group A (20 patients who give
basal treatment), group B (20 patients who give basal and Exenatide treatment, group C（20
patients who give basal and Gastric Bypass treatment). The age, height, weight, blood
glucose, glycosylated hemoglobin A1c（HbA1c）,homeostasis model assessment(HOMA-IR), lipid,
blood pressure, course of disease, ejection fraction (EF), fractional shortening(FS),
diameter of left ventricle in late diastolic stage(LVEDd), the thickness of the ventricular
septa（IVSD) and the posterior wall of the right ventricle in late diastolic stage (LVPWd)
will record respectively. Left ventricular mass index (LVMI), relative wall thickness (RWT)
will calculate and High-sensitive C-reactive protein (HsCRP), adiponectin and Tumor necrosis
factor-α（TNF-α） will detect as Baseline. After each group's treatment, Change from baseline
of all indexes will record, Multifactor logistic regression will be analyzed the
correlations between each positive indexes.
;
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
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