Type 2 Diabetes Clinical Trial
Official title:
VLDL-triglyceride Kinetics and -Metabolism in the Post Absorptive State and During Hyperinsulinemia in Type 2 Diabetes
Type 2 diabetes is associated with diabetic dyslipidemia, which is a major risk factor for
coronary heart disease. Triglycerides (TG) and cholesterol are transported in the system of
lipoproteins, and the metabolism of these lipids in plasma is closely interrelated. Evidence
suggests that increased concentration of very low-density lipoprotein triglyceride (VLDL-TG)
is a central pathophysiological feature of the lipid and lipoprotein abnormalities in
diabetic dyslipidemia.
The objective of this study was to investigate VLDL-TG kinetics and aspects of peripheral
VLDL-TG metabolism, i.e. to what extent VLDL-TG associated fatty acids (FA) are oxidized or
deposited in regional adipose tissue, in subjects with type 2 diabetes and healthy controls
in the postabsorptive state and during acute hyperinsulinemia using ex-vivo labeled VLDL-TG
tracers.
n/a
Observational Model: Case Control, Time Perspective: Prospective
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