Type 2 Diabetes Clinical Trial
Official title:
Exercise - Effects on Health Related Quality of Life, Cardiovascular Risk Factors, and Cellular Functions With Respect to Glucose Metabolism, in Type 2 Diabetes Mellitus, Impaired Glucose Tolerance and in Healthy Individuals.
A sedentary lifestyle is known to be a risk factor to developing type 2 diabetes. The aim of this study was to determine the effects of adding regular Nordic walking to daily physical activity. Effects on quality of life, cardiovascular risk factors and functions in muscle cells will be determined.
Regular physical activity is known to have a beneficial effect on several factors affecting
the risk of developing cardiovascular disease and type 2 diabetes. Implementing and
maintaining changes of lifestyle is, however, known to be difficult. In this study we wished
to investigate the effects of an exercise intervention that is feasible to most people with
type 2 diabetes or at risk of developing that disease. The intervention was Nordic walking
(with walking poles) for five hour per week, during four months. We chose to determine
effects on health related quality of life, clinical parameters related to body weight/body
composition, blood pressure, glucose metabolism, insulin resistance, blood lipids, oxygen
uptake and physiological effects in skeletal muscle cells related to glucose metabolism.
On inclusion and after four months the participants were therefore subject to clinical
measurements, blood samples, maximal oxygen uptake tests on an ergometer cycle and muscle
biopsies at inclusion and after four months of participation. They also answered an
extensive questionnaire focusing on health related quality of life.
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Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Prevention
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