Type 2 Diabetes Clinical Trial
Official title:
Understanding the Acute Effects of Prolonged Sedentary Behaviour (Sitting) on Post-meal Glucose and Lipids - A Pilot Study
A randomised, cross-over trial targeting a small sample of older (age 45-65 years)
overweight adults with type 2 diabetes the aims of this pilot study are to:
1. Determine the feasibility of investigating the acute effects of prolonged sedentary
behaviour (sitting) in this target group.
2. Compare the acute effects of a single prolonged (8 hour) bout of sedentary behaviour
(sitting) on glucose and triglyceride concentrations and key muscle and adipose
regulatory enzymes to a similar bout of sedentary behaviour combined with intermittent
bouts of light-intensity activity.
The proposed study will involve a randomised cross-over experimental trial conducted in the
laboratory setting in older overweight adults with type 2 diabetes. Participants will
receive both of the acute testing conditions in a randomised manner.
Study design: Randomised cross-over pilot trial of 20 overweight/obese older adults with
diet-controlled type 2 diabetes involving 2 acute treatment conditions, with a one-week
wash-out period between testing conditions (Figure 1 a).
Setting: Acute, supervised laboratory setting within the Alfred and Baker Heart Institute
Medical Unit.
Outcomes: We will measure acute responses in laboratory-measured plasma glucose &
triglyceride levels (every 60 mins) and glucose concentrations determined from continuous
glucose monitoring (CGMS).
;
Observational Model: Cohort, Time Perspective: Cross-Sectional
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