Type 2 Diabetes Clinical Trial
Official title:
Impact of 3-year Lifestyle Intervention on Postprandial Glucose Metabolism: the SLIM Study
To evaluate the effect of a 3-year diet- and exercise lifestyle intervention, based on general public health recommendations, on glucose tolerance, insulin resistance and metabolic cardiovascular risk factors in Dutch subjects with impaired glucose tolerance (IGT).
Objective To evaluate the effect of a 3-year diet- and exercise lifestyle intervention,
based on general public health recommendations, on glucose tolerance, insulin resistance and
metabolic cardiovascular risk factors in Dutch subjects with impaired glucose tolerance
(IGT).
Research design and methods 147 IGT subjects (75 male, 72 female) were randomized to the
intervention group (INT) or control group (CON). 106 subjects (52 INT, 54 CON) completed 3
years of intervention. Annually, glucose, insulin and FFA concentrations were determined
during fasting and after an oral glucose tolerance test, in addition to measurements of body
weight, serum lipids, blood pressure and maximal aerobic capacity.
;
Allocation: Randomized, Endpoint Classification: Safety Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Prevention
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